Serum galactomannan testing after bronchoalveolar lavage in the ICU. Is it complementary and necessary or redundant?

Jose Peral Gutiérrez de Ceballosa , Javier Muñoz Gonzálezb

Emergency and Critical Care Medicine ›› 2025, Vol. 5 ›› Issue (4) : 168 -169.

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Emergency and Critical Care Medicine ›› 2025, Vol. 5 ›› Issue (4) :168 -169. DOI: 10.1097/EC9.0000000000000161
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Serum galactomannan testing after bronchoalveolar lavage in the ICU. Is it complementary and necessary or redundant?
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Jose Peral Gutiérrez de Ceballosa, Javier Muñoz Gonzálezb. Serum galactomannan testing after bronchoalveolar lavage in the ICU. Is it complementary and necessary or redundant?. Emergency and Critical Care Medicine, 2025, 5(4): 168-169 DOI:10.1097/EC9.0000000000000161

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The authors declare no conflict of interest.

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The authors have contributed to the writing and review of the topic.

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References

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Maertens J, Maertens V, Theunissen K, et al. Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases. Clin Infect Dis. 2009; 49(11):1688-1693. doi:10.1086/647935

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Wehbe S, Chaftari AM, Hachem R, et al. Prognostic value of serum and bronchoalveolar lavage fluid galactomannan levels in invasive aspergillosis: an 8-year experience at a tertiary cancer center. J Fungi (Basel). 2025; 11(5):355. doi:10.3390/jof11050355

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Zhou W, Li H, Zhang Y, et al. Diagnostic value of galactomannan antigen test in serum and bronchoalveolar lavage fluid samples from patients with nonneutropenic invasive pulmonary aspergillosis. J Clin Microbiol. 2017; 55(7):2153-2161. doi:10.1128/JCM.00345-17

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Heng SC, Morrissey O, Chen SC, et al. Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: a systematic review and meta-analysis. Crit Rev Microbiol. 2015; 41(1):124-134. doi:10.3109/1040841X.2013.804033

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Dai Z, Cai M, Yao Y, et al. Comparing the diagnostic value of bronchoalveolar lavage fluid galactomannan, serum galactomannanan, and serum 1,3-β-d-glucan in non-neutropenic respiratory disease patients with invasive pulmonary aspergillosis. Medicine (Baltimore). 2021; 100(14):e25233. doi:10.1097/MD.0000000000025233

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Hage CA, Carmona EM, Epelbaum O, et al. Microbiological laboratory testing in the diagnosis of fungal infections in pulmonary and critical care practice. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2019; 200(5):535-550. doi:10.1164/rccm.201906-1185ST

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Liu L, Li J, Dong H, et al. Diagnostic value of the combinations of bronchoalveolar lavage fluid galactomannan test and serum galactomannan test in invasive pulmonary aspergillosis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019; 31(3):331-335. doi:10.3760/cma.j.issn.2095-4352.2019.03.014

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