Early sodium bicarbonate therapy for critically ill patients with septic shock and acute moderate metabolic acidosis

Conflict of interest statement

The authors declare no conflict of interest.

Author contributions

The study was designed by Feng C, who was responsible for data collection, analysis, and interpretation and for writing the manuscript. Huang S and Peng Y contributed to data analysis and interpretation and wrote the manuscript. Zhang X conducted the data interpretation. Yao Y performed the data interpretation and reviewed the manuscript.

Funding

None.

Ethical approval of studies and informed consent

Data collection was passive and had no impact on patient safety. The data set was deidentified in compliance with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule. Data extraction from the database was certified by the team at the Laboratory for Computational Physiology at the Massachusetts Institute of Technology (MIT-LCP), which provides and maintains MIMIC-IV. Since the study was an analysis of an anonymized, publicly available third-party database that had already been approved by the Institutional Review Board (IRB), our institution’s IRB approval was exempt.

Acknowledgments

We thank the team at the Laboratory for Computational Physiology from the Massachusetts Institute of Technology (MIT-LCP) for maintaining the MIMIC databases. We also thank the support from the National Natural Science Fund (no. 82072200).

References

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