Current approach to moisturizer and emollient utilization in atopic dermatitis: a review

Serap Maden

Exploration of Asthma & Allergy ›› 2024, Vol. 2 ›› Issue (5) : 441 -449.

PDF (2402KB)
Exploration of Asthma & Allergy ›› 2024, Vol. 2 ›› Issue (5) :441 -449. DOI: 10.37349/eaa.2024.00056
Open Access Review
research-article
Current approach to moisturizer and emollient utilization in atopic dermatitis: a review
Author information +
History +
PDF (2402KB)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that primarily affects the barrier function of the skin in patients. The condition has been documented to cause xerosis in patients from birth onwards. In order to protect the skin barrier in AD, it is of the utmost importance to moisturize the skin. Moisturizers and emollients play a pivotal role in the prevention and treatment of AD. Concordantly, the use of moisturizers and emollients can facilitate the reduction in the necessity for the application of topical treatments such as corticosteroids. An understanding of the use of moisturizers and emollients, in conjunction with an appreciation of the pathophysiology of the skin barrier, will prove invaluable in the treatment of AD.

Keywords

Atopic dermatitis / moisturizer / emollient / treatment

Cite this article

Download citation ▾
Serap Maden. Current approach to moisturizer and emollient utilization in atopic dermatitis: a review. Exploration of Asthma & Allergy, 2024, 2 (5) : 441-449 DOI:10.37349/eaa.2024.00056

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Hülpüsch C, Rohayem R, Reiger M, Traidl-Hoffmann C. Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification. J Allergy Clin Immunol. 2024; 154: 31-41.

[2]

Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å. Prevalence and incidence of atopic dermatitis: a systematic review. Acta Derm Venereol. 2020; 100: adv00160.

[3]

Ramírez-Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatr Dermatol. 2022; 39: 345-53.

[4]

Sacotte R, Silverberg JI. Epidemiology of adult atopic dermatitis. Clin Dermatol. 2018; 36: 595-605.

[5]

Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol. 2017; 137: 26-30.

[6]

Nakashima C, Yanagihara S, Otsuka A. Innovation in the treatment of atopic dermatitis: Emerging topical and oral Janus kinase inhibitors. Allergol Int. 2022; 71: 40-6.

[7]

Otsuka A, Nomura T, Rerknimitr P, Seidel JA, Honda T, Kabashima K. The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis. Immunol Rev. 2017; 278: 246-62.

[8]

Kim BE, Leung DYM. Significance of Skin Barrier Dysfunction in Atopic Dermatitis. Allergy Asthma Immunol Res. 2018; 10: 207-15.

[9]

Fania L, Moretta G, Antonelli F, Scala E, Abeni D, Albanesi C, et al. Multiple Roles for Cytokines in Atopic Dermatitis: From Pathogenic Mediators to Endotype-Specific Biomarkers to Therapeutic Targets. Int J Mol Sci. 2022; 23: 2684.

[10]

van Zuuren EJ, Fedorowicz Z, Arents BWM. Emollients and moisturizers for eczema: abridged Cochrane systematic review including GRADE assessments. Br J Dermatol. 2017; 177: 1256-71.

[11]

Lowe AJ, Leung DYM, Tang MLK, Su JC, Allen KJ. The skin as a target for prevention of the atopic march. Ann Allergy Asthma Immunol. 2018; 120: 145-51.

[12]

Rajkumar J, Chandan N, Lio P, Shi V. The skin barrier and moisturization: Function, disruption, and mechanisms of repair. Skin Pharmacol Physiol. 2023; 36: 174-85.

[13]

Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014; 71: 116-32.

[14]

Kang SY, Um JY, Chung BY, Lee SY, Park JS, Kim JC, et al. Moisturizer in Patients with Inflammatory Skin Diseases. Medicina (Kaunas). 2022; 58: 888.

[15]

Hon KL, Wang SS, Pong NH, Leung TF. The ideal moisturizer: a survey of parental expectations and practice in childhood-onset eczema. J Dermatolog Treat. 2013; 24: 7-12.

[16]

Proksch E. Prevention of AD in early childhood: Finding the right emollient and the right usage. J Eur Acad Dermatol Venereol. 2023; 37: 2403-4.

[17]

van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM. Emollients and moisturisers for eczema. Cochrane Database Syst Rev. 2017; 2: CD012119.

[18]

Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003; 4: 771-88.

[19]

Kelleher MM, Phillips R, Brown SJ, Cro S, Cornelius V, Carlsen KCL, et al. Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database Syst Rev. 2022; 11: CD013534.

[20]

Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema - part II: non-systemic treatments and treatment recommendations for special AE patient populations. J Eur Acad Dermatol Venereol. 2022; 36: 1904-26.

[21]

Halling-Overgaard AS, Kezic S, Jakasa I, Engebretsen KA, Maibach H, Thyssen JP. Skin absorption through atopic dermatitis skin: a systematic review. Br J Dermatol. 2017; 177: 84-106.

[22]

Danby SG, Andrew PV, Taylor RN, Kay LJ, Chittock J, Pinnock A, et al. Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis. Clin Exp Dermatol. 2022; 47: 1154-64.

[23]

Chalmers JR, Haines RH, Bradshaw LE, Montgomery AA, Thomas KS, Brown SJ, et al. Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. Lancet. 2020; 395: 962-72.

[24]

Bradshaw LE, Wyatt LA, Brown SJ, Haines RH, Montgomery AA, Perkin MR, et al. Emollients for prevention of atopic dermatitis: 5-year findings from the BEEP randomized trial. Allergy. 2023; 78: 995-1006.

[25]

Goh CL, Wu Y, Welsh B, Abad-Casintahan MF, Tseng CJ, Sharad J, et al. Expert consensus on holistic skin care routine: Focus on acne, rosacea, atopic dermatitis, and sensitive skin syndrome. J Cosmet Dermatol. 2023; 22: 45-54.

[26]

Draelos ZD. The science behind skin care: Moisturizers. J Cosmet Dermatol. 2018; 17: 138-44.

[27]

Araviiskaia E, Pincelli C, Sparavigna A, Luger T. The Role of a Novel Generation of Emollients, ‘Emollients Plus’, in Atopic Dermatitis. Clin Cosmet Investig Dermatol. 2022; 15: 2705.

[28]

Hon KL, Kung JSC, Ng WGG, Leung TF. Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs Context. 2018; 7: 2125-30.

PDF (2402KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/