Electrowetting-on-dielectric (EWOD) enables electrical modulation of liquid contact angle and is widely used for droplet actuation; however, its reliance on bulky high-voltage power supplies limits portability. Triboelectric nanogenerators (TENGs) provide a lightweight, mechanically driven alternative, yet existing EWOD–TENG systems still rely on electronic controllers or rapid manual actions. Here, we present a hand-powered and mechanically programmable EWOD platform that integrates a contact-separation TENG (CS-TENG) with a mechanically encoded punch-card switch array, both driven by a single hand-crank mechanism. Hand cranking simultaneously generates high voltage for EWOD actuation and advances a punch-card tape to sequentially trigger electrode switching according to predefined punch-hole patterns. Unlike conventional voltage sources, the CS-TENG delivers a constant-charge output per cycle, leading to distinct EWOD behavior. An EWOD–TENG model with trapped charge elucidates key phenomena, including bias-dependent asymmetric EWOD arising from dielectric charge trapping and stepwise voltage attenuation caused by capacitive EWOD loading during sequential switching. The punch-card switch array converts physical hole patterns into time-synchronized electrode activation, enabling programmable droplet manipulation without electronic controllers. The resulting platform executes predefined droplet operations using only a hand crank as the sole energy and control input, achieving autonomous, portable, and robust droplet control for field-deployable microfluidic systems.
| [1] |
Mugele F, Baret JC. Electrowetting: from basics to applications. J Phys: Condens Matter. 2005; 17: R705-R774.
|
| [2] |
Nelson WC, Kim CJ. Droplet actuation by electrowetting-on-dielectric (EWOD): a review. J Adhes Sci Technol. 2012; 26: 1747-1771.
|
| [3] |
Zhao Y-P, Wang Y. Fundamentals and applications of electrowetting: a critical review. Rev Adhes Adhes. 2013; 1: 114-174.
|
| [4] |
Chen L, Bonaccurso E. Electrowetting—from statics to dynamics. Adv Colloid Interface Sci. 2014; 210: 2-12.
|
| [5] |
Teng P, Tian D, Fu H, Wang S. Recent progress of electrowetting for droplet manipulation: from wetting to superwetting systems. Mater Chem Front. 2020; 4: 140-154.
|
| [6] |
Barman SR, Khan I, Chatterjee S, et al. Electrowetting-on-dielectric (EWOD): current perspectives and applications in ensuring food safety. J Food Drug Anal. 2020; 28: 595-621.
|
| [7] |
Zhao Y-R, Li Z-S, Zheng Y, et al. Non-aqueous electrowetting liquid lens with centimeter-level large aperture based on dielectric failure suppression principle. Light Sci Appl. 2025; 14: 120.
|
| [8] |
Fair RB. Digital microfluidics: is a true lab-on-a-chip possible? Microfluid Nanofluid. 2007; 3: 245-281.
|
| [9] |
Abdelgawad M, Wheeler AR. The digital revolution: a new paradigm for microfluidics. Adv Mater. 2009; 21: 920-925.
|
| [10] |
Choi K, Ng AH, Fobel R, Wheeler AR. Digital microfluidics. Annu Rev Anal Chem. 2012; 5: 413-440.
|
| [11] |
Kaler KV, Prakash R. Droplet microfluidics for chip-based diagnostics. Sensors. 2014; 14: 23283-23306.
|
| [12] |
Hennig R, Cacucciolo V, Shea H. Actuating droplets with electrowetting: force and dynamics. Droplet. 2024; 3:e108.
|
| [13] |
Vallet M, Berge B, Vovelle L. Electrowetting of water and aqueous solutions on poly(ethylene terephthalate) insulating films. Polymer. 1996; 37: 2465-2470.
|
| [14] |
Min X, Kim WS. Beyond high voltage in the digital microfluidic devices for an integrated portable sensing system. Microfluid Nanofluid. 2019; 23: 127.
|
| [15] |
Drygiannakis AI, Papathanasiou AG, Boudouvis AG. On the connection between dielectric breakdown strength, trapping of charge, and contact angle saturation in electrowetting. Langmuir. 2009; 25: 147-152.
|
| [16] |
Lee CP, Chen HC, Lai MF. Electrowetting on dielectric driven droplet resonance and mixing enhancement in parallel-plate configuration. Biomicrofluidics. 2012; 6:012814.
|
| [17] |
Li J, Kim CJ. Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics. Lab Chip. 2020; 20: 1705-1712.
|
| [18] |
Fan F-R, Tian Z-Q, Wang ZL. Flexible triboelectric generator. Nano Energy. 2012; 1: 328-334.
|
| [19] |
Wang ZL. Triboelectric nanogenerators as new energy technology and self-powered sensors—principles, problems and perspectives. Farad Discuss. 2014; 176: 447-458.
|
| [20] |
Wang ZL. On maxwell's displacement current for energy and sensors: the origin of nanogenerators. Mater Today. 2017; 20: 74-82.
|
| [21] |
Lin Z, Yang Z. Water droplet energy harvesting. Droplet. 2024; 3:e97.
|
| [22] |
Yu A, Zhu Y, Wang W, Zhai J. Progress in triboelectric materials: toward high performance and widespread applications. Adv Funct Mater. 2019; 29:1900098.
|
| [23] |
Peng F, Liu D, Zhao W, et al. Facile fabrication of triboelectric nanogenerator based on low-cost thermoplastic polymeric fabrics for large-area energy harvesting and self-powered sensing. Nano Energy. 2019; 65:104068.
|
| [24] |
Khanapurarm UK, Rani GM, Panda S, et al. Harvesting energy from friction: the revolutionary decade of triboelectric nanogenerators. Adv Powder Mater. 2026; 5:100373.
|
| [25] |
Kulandaivel A, Potu S, Rajaboina RK, Khanapuram UK. Exploring wettability: a key to optimizing liquid‒solid triboelectric nanogenerators. ACS Appl Mater Interfaces. 2024; 16: 58029-58059.
|
| [26] |
Kulandaivel A, Potu S, Babu A, et al. Advances in ferrofluid-based triboelectric nanogenerators: design, performance, and prospects for energy harvesting applications. Nano Energy. 2024; 120:109110.
|
| [27] |
Zheng L, Wu Y, Chen X, et al. Self-powered electrostatic actuation systems for manipulating the movement of both microfluid and solid objects by using triboelectric nanogenerator. Adv Funct Mater. 2017; 27:1606408.
|
| [28] |
Nie J, Ren Z, Shao J, et al. Self-powered microfluidic transport system based on triboelectric nanogenerator and electrowetting technique. ACS Nano. 2018; 12: 1491-1499.
|
| [29] |
Chen G, Liu X, Li S, Dong M, Jiang D. A droplet energy harvesting and actuation system for self-powered digital microfluidics. Lab Chip. 2018; 18: 1026-1034.
|
| [30] |
Yu J, Wei X, Guo Y, et al. Self-powered droplet manipulation system for microfluidics based on triboelectric nanogenerator harvesting rotary energy. Lab Chip. 2021; 21: 284-295.
|
| [31] |
Sun J, Zhao Q, Mo Z, Chen J, Guo H, Zhang L. Self-powered droplet manipulation for full human‒droplet interaction in multiple mediums. Nat Commun. 2025; 16: 2312.
|
| [32] |
Jiang CM, Wu C, Li XJ, et al. All-electrospun flexible triboelectric nanogenerator based on metallic mxene nanosheets. Nano Energy. 2019; 59: 268-276.
|
| [33] |
Nie J, Ren Z, Bai Y, et al. Long distance transport of microdroplets and precise microfluidic patterning based on triboelectric nanogenerator. Adv Mater Technol. 2019; 4:1800300.
|
| [34] |
Yang T-J, Lin Z-H, Lu Y-W. Self-powered digital microfluidics driven by rotational triboelectric nanogenerator. Nano Energy. 2023; 110:108376.
|
| [35] |
Wang C, Li X, Qiu Y, et al. Electrowetting-on-dielectric powered by triboelectric nanogenerator. Nano Energy. 2022; 98:107310.
|
| [36] |
Tan J, Sun S, Jiang D, et al. Advances in triboelectric nanogenerator powered electrowetting-on-dielectric devices: mechanism, structures, and applications. Mater Today. 2022; 58: 201-220.
|
| [37] |
Casey RS, Perry JW. Punched Cards: Their Applications to Science and Industry. Reinhold; 1951.
|
| [38] |
Hobsbawm EJ. The Age of Revolution: Europe 1789–1848. Praeger Publishers; 1962.
|
| [39] |
Sobel R. Thomas Watson, Sr.: IBM and the Computer Revolution. BeardBooks; 1981.
|
| [40] |
Cortada JW. Before the Computer: IBM, NCR, Burroughs, and Remington Rand and the Industry They Created, 1865–1956. Princeton University Press; 2000.
|
| [41] |
Korir G, Prakash M. Punch card programmable microfluidics. PLoS One. 2015; 10:e0115993.
|
| [42] |
Jang L-S, Hsu C-Y, Chen C-H. Effect of electrode geometry on performance of EWOD device driven by battery-based system. Biomed Microdevices. 2009; 11: 1029-1036.
|
| [43] |
Grant N, Geiss B, Field S, Demann A, Chen TW. Design of a hand-held and battery-operated digital microfluidic device using EWOD for lab-on-a-chip applications. Micromachines. 2021; 12: 1065.
|
| [44] |
Banpurkar AG, Sawane Y, Wadhai SM, et al. Spontaneous electrification of fluoropolymer‒water interfaces probed by electrowetting. Farad Discuss. 2017; 199: 29-47.
|
| [45] |
Yuan X, Tang B, Barman J, Groenewold J, Zhou G. Approximately symmetric electrowetting on an oil-lubricated surface. RSC Adv. 2020; 10: 20257-20263.
|
| [46] |
Niu S, Wang ZL. Theoretical systems of triboelectric nanogenerators. Nano Energy. 2015; 14: 161-192.
|
| [47] |
Ding J, Tao W-Q, Fan S-K. Study of vibrational droplet triboelectric nanogenerator on structural and operational parameters. Nano Energy. 2020; 70:104473.
|
| [48] |
Lee J, Moon H, Fowler J, Schoellhammer T, Kim C-J. Electrowetting and electrowetting-on-dielectric for microscale liquid handling. Sens Actuators A Phys. 2002; 95: 259-268.
|
| [49] |
Eral HB, ’t Mannetje D, Oh JM. Contact angle hysteresis: a review of fundamentals and applications. Colloid Polym Sci. 2013; 291: 247-260.
|
| [50] |
Li F, Mugele F. How to make sticky surfaces slippery: contact angle hysteresis in electrowetting with alternating voltage. Appl Phys Lett. 2008; 92:244108.
|
| [51] |
Dong C, Jia Y, Gao J, et al. A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips. Lab Chip. 2017; 17: 896-904.
|
| [52] |
Luan S, Munk-Nielsen S, Yan Z, et al. Design guidelines to reduce parasitic capacitance in planar inductors. 2023 IEEE Applied Power Electronics Conference and Exposition (APEC), Orlando, USA, 2023: 1579-1585.
|
| [53] |
Tran Nguyen PL, Kusaka K. Reduction of parasitic capacitance in pcb planar inductor based on geometry considerations. EMCJ. 2025; 125: 9-14.
|
| [54] |
Kim JH, Lee TI, Kim TS, Paik KW. The effect of anisotropic conductive films adhesion on the bending reliability of chip-in-flex packages for wearable electronics applications. IEEE Trans Compon Packaging Manuf Technol. 2017; 7: 1583-1591.
|
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2026 The Author(s). Droplet published by Jilin University and John Wiley & Sons Australia, Ltd.