Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application

Yixuan Lu; Yaru Guo; Xiaohua Guo; Shihan Zhang; Fangyong Liu; Shuai Ding; Dandan Wang; Yanpei Wang; Kongliang Li; Yuchen Wang; Youxing Liu; Xuliang Deng

doi:10.1016/j.dtrs.2025.100008

Dental Research ›› 2026, Vol. 1 ›› Issue (1) :30 -40. DOI: 10.1016/j.dtrs.2025.100008

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Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application

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^a School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University , Beijing 100871, China

^b Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology , Beijing 100029, China

^c Department of Chemistry, New York University , New York City, NY 10003, USA

^d NMPA Key Laboratory for Dental Materials, Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology , Beijing 100081, China

^e National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology , Beijing 100081, China

^* Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology, Beijing 100029, PR China. E-mail addresses:liuyxpost@pku.edu.cn (Y. Liu).

^** School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing 100871, China. E-mail addresses: kqdengxuliang@bjmu.edu.cn (X. Deng).

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Abstract

The overuse of antibiotics has led to the emergence of drug-resistant bacteria, posing a serious threat to human health and increasing the medical burden. Metal-organic frameworks (MOFs) have shown great potential as enzyme mimics for antibacterial applications; however, their performance is often limited by the low density and poor accessibility of active sites. Herein, we report an innovative surface-active agent intercalation-assisted confinement growth strategy for constructing two-dimensional (2D) NH₂-BDC-Cu, Fe nanosheets (NSs) with highly exposed active site to enhance reactive oxygen species (ROS) generation, thereby improving the antibacterial efficiency against drug-resistant bacteria. We demonstrate that the synthesized 2D NH₂-BDC-Cu, Fe NSs exhibit 6.6-fold higher ROS production compared to NH₂-BDC-Cu, Fe nanopowders (NPs). Consequently, NH₂-BDC-Cu, Fe NSs achieve 100% antibacterial activity against both Staphylococcus aureus and Escherichia coli within 1 h, markedly outperforming NH₂-BDC-Cu, Fe NPs and previously reported biomaterials. Moreover,in vivo experiments confirm that NH₂-BDC-Cu, Fe NSs accelerate wound healing, achieving a 100% healing rate within 10 days, which is substantially higher than that of NH₂-BDC-Cu, Fe NPs. Overall, this work introduces a novel and efficient strategy for fabricating 2D MOF nanoenzymes with high active-site exposure, offering great promise for the development of advanced biomaterial-based antibacterial therapies.

Keywords

Metal-organic frameworks / Two-dimensional / Self-assembly / Antibacterial / Wound healing

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Yixuan Lu, Yaru Guo, Xiaohua Guo, Shihan Zhang, Fangyong Liu, Shuai Ding, Dandan Wang, Yanpei Wang, Kongliang Li, Yuchen Wang, Youxing Liu, Xuliang Deng. Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application. Dental Research, 2026, 1 (1) : 30-40 DOI:10.1016/j.dtrs.2025.100008

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