Colon cancer is one of the top three malignant tumors in the world, in recent years, the incidence and mortality of this disease are increasing, which seriously threatens human life and health. At present, surgery is still the main treatment for colon cancer, combined with chemotherapy and other measures can effectively improve the survival of patients. Different surgical methods have different prognostic effects on patients. In terms of intraoperative lymph node dissection for colon cancer, lymph node dissection during total mesocolic resection and D3 radical resection has significantly improved prognosis for colon cancer. Lymph node metastasis of colon cancer is common, with the presence of skip metastasis, lymph node dissection is important for the prognosis of patients, tumor recurrence and tumor metastasis. Therefore, it is necessary to make clear the diagnosis and lymph node metastasis before surgery, determine the surgical procedure and the scope of lymph node dissection, so as to avoid postoperative complications caused by inadequate tumor recurrence or excessive clearance.
Objective: To establish a nursing service model of 37℃ “six-center service” and study the effect of this model on improving nursing services in the course of nursing work.
Methods: The semi-structured interview method and group meeting method are used to establish the 37℃ nursing service model and implement the “general health” concept of “benevolence-based and central enterprise quality.” The newly established 37℃ “six-center service” (enthusiastic reception, patient explanation, careful observation, sincere help, warm-hearted delivery and heart-to-heart visit) nursing model in the comprehensive ward of Baogang Hospital (Inner Mongolia) runs through the three phases of patient admission, hospitalization and discharge, providing patients with warm care services, so that patients can truly enjoy the warmth of 37℃ nursing and friendly family flair during the peri-hospitalization period.
Results: (1) The established 37℃ “six-heart service” nursing service model has been treated as a nursing service path and is widely used in the hospital; (2) After the implementation of the 37℃ nursing service, patients, nurses, doctors, hospitals and the society show an effectively improved satisfaction; (3) The 37℃ “six-heart service” nursing service model is established as a hospital nursing service brand; (4) The 37℃ “six-heart service” nursing service brand has received enthusiastic responses in Baotou, Health Management Technology Co., Ltd. and GENERTEC.
Conclusions: The established 37℃ “six-heart service” nursing service model can effectively improve the quality of nursing service and establish a nursing service brand, which can be promoted across the country.
Inflammation is generally considered as a pathological process, and the occurrence of multi-organ inflammatory diseases is usually accompanied by an inflammatory response. Persistent inflammation can eventually lead to organ dysfunction. In recent years, the study of mesenchymal stem cell-derived exosomes has found its unique anti-inflammatory effect, which provides a new idea for the treatment of multi-organ inflammatory diseases. This article reviews the effect of mesenchymal stem cell exosomes on multi-organ inflammatory diseases.
Objective: To investigate the effect of liraglutide on diabetic nephropathy in rats and its regulatory mechanism.
Methods: The diabetic nephropathy rat model was constructed with high-glucose-high-fat diet in combination with STZ, and was randomly divided into normal saline group and liraglutide group. The rats in liraglutide group were given sc 200 μg/kg of liraglutide, and the rats in normal saline group were given sc 20 mg/kg of normal saline twice a day for 4 weeks. The normal control group was not treated with any treatment. The biochemical indexes such as rat body weight, 24-hour urine total protein quantification (UTP), fasting blood glucose (FPG), triglyceride (TG), cholesterol (TC), blood urea nitrogen (BUN) and serum creatinine (Scr) were measured. HE staining, Masson staining and PAS staining were used to observe the pathologically morphological changes in renal tissues. Western-blot was used to detect the expression of NLRP3 inflammasome-related protein in renal tissues. Elisa was used to measure the serum levels of interleukin-18 (IL-18) and IL-1β. SPSS 26.0 statistical software and Graph Prism 9.0 software were used for analysis and mapping. The t-test was used for the comparison of measurement data between two groups, one-way ANOVA was used for the comparison among multiple groups, and Tukey’s test was used for the comparison in the same group.
Results: Compared with the normal saline group, FBG, UTP, BUN, Scr, TC and TG in the liraglutide group were significantly decreased (p <.01), the glomerular basement membrane was slightly thickened, with the tubular lumen slightly dilated and the lesion damage alleviated; the expression levels of NLRP3, ASC andCaspase-1 inflammasome-related proteins were decreased (p <.01), and the levels of IL-18 and IL-1β were decreased (p <.01).
Conclusions: Liraglutide can inhibit the activation of NLRP3 inflammasome mediated by oxidative stress in renal tissues through ROS-NLRP3 inflammasome pathway, thereby inhibiting the inflammation, and finally playing an anti-diabetic nephropathy renal injury role.
Cell therapy represents an important area of biotechnology, with the potential to treat and even cure a variety of diseases that cannot be cured by traditional therapies. Cell therapy is currently a widely studied treatment in both preclinical and clinical settings, and many cell therapy products are undergoing clinical trials. This article reviews the application of cell therapy in a variety of diseases and the policy of stem cell therapy in China.