We present a 2,440 g male neonate born by caesarian section at 38 weeks of gestational age. Baby had been diagnosed with giant exomphalos during prenatal scans. Due to the giant size of the exomphalos with liver being sac content to more than 50% and severe degree of abdominovisceral disproportion, the decision was made to adopt a staged-treatment approach. We created an external silo supplemented with DuoDERM compression dressings and adjusted it over three weekly sessions. The exomphalos was completely reduced, and the patient underwent delayed primary closure A modified single-layer abdominal wall repair was carried out uneventfully. The post-operative period was uncomplicated and at follow-up 4 years later the patient had no incisional hernia and is thriving well.
Periodontal disease is a chronic infectious disease, which is common and frequent disease in pregnant women. It is an infectious disease caused by a variety of microorganisms, and the physiological changes in pregnant women after pregnancy can promote the occurrence and development of periodontal disease. Women no less than 35 years old are at an increased risk of maternal and fetal complications in pregnancy, older pregnant women with periodontal disease are prone to preterm birth, fetal growth retardation, premature rupture of membranes, and the incidence of neonatal low birth weight is significantly higher than that in older women with healthy oral health,i.e., these risks are increased with age. C-reactive protein (CRP) is an acute-phase protein produced by liver organs, which is produced by hepatocytes under the promotion of inflammatory factors, and serves as the most direct and sensitive marker of inflammatory response. Studies have shown that basic periodontal treatment relieve periodontal tissue inflammation in pregnant women with periodontitis, while significantly reducing their serum CRP concentration, thereby decreasing the occurrence of adverse pregnancy outcomes. The objective of this study is to investigate the effect of basic periodontal treatment on CRP in elderly pregnant women with periodontal disease.
Objective: To explore the combined effects of multisensory intervention and amplitude integrated electroencephalogram monitoring on the maturation and evaluation of brain and neural development in premature infants of different gestational ages.
Methods: The controlled trial was carried out in 62 premature infants from January to February of 2023 in Genertec AMHT - Baogang Hospital. The premature infants were divided into two groups according to the gestational age: 32-33+6W (Group A) and 34-36+6W (Group B). By use of random number table method, each group was subdivided into the control group and the experimental group. The control group was monitored with aEEG within 1 day and the following 7 days after birth. The experimental group was monitored with aEEG within 1 day and the following 7 days after multisensory intervention (MS) to observe the change of aEEG parameters, in order to explore the effect of MS intervention on brain development maturity. The Neonatal Behavioral Neurological Assessment (NBNA) score was performed at 40 weeks of corrected gestational age in both groups.
Results: The amplitude voltage, the total aEEG score and the sleep-wake cycle score in the experimental group were higher than those in the control group (p<.05). The total NBNA score in the experimental group was higher than that in the control group.
Conclusions: The multi-sensory intervention is a simple and feasible method of development support nursing, it can improve the total NBNA score of premature infants, which can promote the brain development in premature infants and improve their neurodevelopmental behavior.
Objective: To explore the effect and mechanism of donepezil hydrochloride on Alzheimer’s disease (AD).
Methods: Thirty-six 3-month-old SD rats were selected as the research subjects and randomly divided into a normal control (NC) group and a model group. The model group was given continuous intraperitoneal injection of D-galactose solution (120 mg/kg/d) combined with aluminum trichloride (10 mg/kg/d) by gavage for 60 days. Morris water maze test was conducted to test the learning and memory abilities of the rats, and AD rats were selected. After modeling, AD rats were divided into a normal saline (NS) group and a drug treatment (DT) group. The DT group was given donepezil hydrochloride (1.0 mg/kg) by gavage intervention, and the NC group and the NS group were given equal volumes of physiological saline by gavage. After 4 weeks of intervention, Morris water maze test was conducted to detect the escape latency, the number of platform crossings and residence time in the target quadrant, the rats were euthanized, with serum and hippocampal tissues collected, and hippocampal tissue homogenate (10%) was prepared by using NS. Enzyme linked immunosorbent assay (ELISA) was used to detect the inflammatory and oxidative stress indicators in rat hippocampal tissues and serum, and hematoxylin eosin (HE) staining was used to observe pathological damage in rat hippocampal tissues.
Results: Compared with the NC group, the NS group showed a significant increase in escape latency (p<.05), a significant decrease in the number of platform crossings and residence time in the target quadrant (p<.05), and a significant decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum and hippocampal tissues (p<.05). The content of malondialdehyde (MDA) was significantly increased (p<.05), and the levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) were significantly increased (p<.05). Compared with the NS group, the DT group can significantly reduce the escape latency (p<.05), increase the number of platform crossings and residence time in the target quadrant (p<.05), significantly increase the activities of SOD and GSH-Px in serum and hippocampal tissues and reduce the content of MDA (p<.05) and the levels of IL-6 and TNF-α (p<.05). After intervention with donepezil hydrochloride, the number of neurons in the hippocampus were significantly increased.
Conclusions: Donepezil hydrochloride can improve the learning and memory abilities of rats, reduce the levels of oxidative stress and inflammation in the brain and serum, and improve pathological damage in the hippocampus.