Timing of Complete Revascularization in STEMI: Insights From the OPTION-STEMI Trial

References

[1] Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al.. 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J. 2023. Vol. 44(38):3720-826

[2] Wald DS, Morris JK, Wald NJ, Chase AJ, Edwards RJ, Hughes LO, et al.. Randomized trial of preventive angioplasty in myocardial infarction. N Engl J Med. 2013. Vol. 369(12):1115-23

[3] Gershlick AH, Khan JN, Kelly DJ, Greenwood JP, Sasikaran T, Curzen N, et al.. Randomized trial of complete versus lesion-only revascularization in patients undergoing primary PCI for STEMI and multivessel disease (CvLPRIT). J Am Coll Cardiol. 2015. Vol. 65(10):963-72

[4] Engstrøm T, Kelbæk H, Helqvist S, Høfsten DE, Kløvgaard L, Holmvang L, et al.. Complete revascularisation versus treatment of the culprit lesion only in patients with STEMI and multivessel disease (DANAMI-3-PRIMULTI). Lancet. 2015. Vol. 386(9994):665-71

[5] Smits PC, Abdel-Wahab M, Neumann FJ, Boxma-de Klerk BM, Lunde K, Schotborgh CE, et al.. Fractional flow reserve-guided multivessel angioplasty in myocardial infarction. N Engl J Med. 2017. Vol. 376(13):1234-44

[6] Mehta SR, Wood DA, Storey RF, Mehran R, Bainey KR, Nguyen H, et al.. Complete revascularization with multivessel PCI for myocardial infarction. N Engl J Med. 2019. Vol. 381(15):1411-21

[7] Stähli BE, Varbella F, Linke A, Schwarz B, Felix SB, Seiffert M, et al.. Timing of complete revascularization with multivessel pci for myocardial infarction. N Engl J Med. 2023. Vol. 389:1368-79

[8] Diletti R, den Dekker WK, Bennett J, Schotborgh CE, van der Schaaf R, Sabaté M, et al.. Immediate versus staged complete revascularisation in patients presenting with acute coronary syndrome and multivessel coronary disease (BIOVASC): a prospective, open-label, non-inferiority, randomised trial. Lancet. 2023. Vol. 401:1172-82

[9] Kim MC, Ahn JH, Hyun DY, Lim Y, Lee SH, Oh S, et al.. Timing of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction with multivessel disease: rationale and design of the OPTION-STEMI trial. Am Heart J. 2024. Vol. 273:35-43

[10] Kim MC, Ahn JH, Hyun DY, Lim Y, Cho KH, Lee SH, et al.. Immediate versus staged complete revascularisation during index admission in patients with STEMI and multivessel disease (OPTION-STEMI). Lancet. 2025. Vol. 406(10507):1032-43

[11] Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al.. 2025. ACC/AHA/ACEP/NAEMSP/SCAI guideline for the management of patients with acute coronary syndromes: a report of the american college of cardiology/american heart association joint committee on clinical practice guidelines. Circulation. 2025. Vol. 151(13):e771-862