Microplastics crossing the blood-testis barrier: A call to action for urological research

Benjamin Koff , Jamie Kim , Robert White , Tal Cohen

Current Urology ›› 2026, Vol. 20 ›› Issue (2) : 89 -90.

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Current Urology ›› 2026, Vol. 20 ›› Issue (2) :89 -90. DOI: 10.1097/CU9.0000000000000318
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Microplastics crossing the blood-testis barrier: A call to action for urological research
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Benjamin Koff, Jamie Kim, Robert White, Tal Cohen. Microplastics crossing the blood-testis barrier: A call to action for urological research. Current Urology, 2026, 20(2): 89-90 DOI:10.1097/CU9.0000000000000318

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Acknowledgments

None.

Statement of ethics

Not applicable.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Funding source

None.

Author contributions

BK: Investigation, methodology development, original draft writing, and manuscript review and editing;

JK: Investigation, methodology development, and project administration;

RW: Oversaw project administration and contributed to manuscript review and editing;

TC: Manuscript review and editing. All authors have read and approved the final manuscript.

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

References

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Mahmud F, Sarker DB, Jocelyn JA, Sang QA. Molecular and cellular effects of microplastics and nanoplastics: focus on inflammation and senescence. Cells 2024; 13(21):1788.

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Kopatz V, Wen K, Kovács T, et al. Micro- and nanoplastics breach the blood-brain barrier (BBB): biomolecular corona’s role revealed. Nanomaterials (Basel) 2023; 13(8):1404.

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Gao L, Xiong X, Chen C, et al. The male reproductive toxicity after nanoplastics and microplastics exposure: sperm quality and changes of different cells in testis. Ecotoxicol Environ Saf 2023;267:115618.

[4]

Değermenci M, Baş O, İlhan H, et al. Toxic effects of immunofluorescent polystyrene nanoplastics on rat testicular tissue. Bratisl Med J 2025; 126(8):1801-1811.

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Hu R, Yao C, Li Y, et al. Polystyrene nanoplastics promote CHIP-mediated degradation of tight junction proteins by activating IRE1α/XBP1s pathway in mouse Sertoli cells. Ecotoxicol Environ Saf 2022;248:114332.

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Jørgensen N, Lamb DJ, Levine H, et al. Are worldwide sperm counts declining? Fertil Steril 2021; 116(6):1457-1463.

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