Systemic single-cell analysis of GPP reveals treatment-responsive and persistent immune signatures

Soyoung Jeong; Seungbok Lee; Christine Suh-Yun Joh; James G. Krueger; Hyun Je Kim; Seong Jin Jo; Jong-Hee Chae

doi:10.1002/ctm2.70753

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (8) :e70753 DOI: 10.1002/ctm2.70753

LETTER TO THE JOURNAL

Systemic single-cell analysis of GPP reveals treatment-responsive and persistent immune signatures

Soyoung Jeong ¹^,²
, Seungbok Lee ³^,⁴
, Christine Suh-Yun Joh ¹
, James G. Krueger ⁵
, Hyun Je Kim ¹^,⁶^,⁷^,⁸^,⁹
, Seong Jin Jo ⁷^,¹⁰^,¹¹
, Jong-Hee Chae ³^,⁴

Author information +

¹. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea

². Genomic Medicine Institute, Seoul National University Medical Research Center, Seoul, South Korea

³. Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, South Korea

⁴. Department of Genomic Medicine, Seoul National University Hospital, Seoul, South Korea

⁵. Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York, USA

⁶. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea

⁷. Department of Dermatology, Seoul National University Hospital, Seoul, South Korea

⁸. Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea

⁹. Interdisciplinary Program in Artificial Intelligence (IPAI), Seoul National University, Seoul, South Korea

¹⁰. Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea

¹¹. Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, South Korea

hjkim0518@gmail.com

sj.jo@snu.ac.kr

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Keywords

generalised pustular psoriasis / IL-12/23 blockade / IL-17A blockade / single-cell RNA sequencing / treatment response

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Soyoung Jeong, Seungbok Lee, Christine Suh-Yun Joh, James G. Krueger, Hyun Je Kim, Seong Jin Jo, Jong-Hee Chae. Systemic single-cell analysis of GPP reveals treatment-responsive and persistent immune signatures. Clinical and Translational Medicine, 2026, 16 (8) : e70753 DOI:10.1002/ctm2.70753

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References

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.