The emerging dialogue between synthetic genomics and clinical research

Yue Liu; Ying-Jin Yuan

doi:10.1002/ctm2.70738

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (7) :e70738 DOI: 10.1002/ctm2.70738

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The emerging dialogue between synthetic genomics and clinical research

Yue Liu ¹^,²
, Ying-Jin Yuan ¹^,²

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Yue Liu, Ying-Jin Yuan. The emerging dialogue between synthetic genomics and clinical research. Clinical and Translational Medicine, 2026, 16 (7) : e70738 DOI:10.1002/ctm2.70738

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References

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[1]	Dewey FE, Grove ME, Pan C, et al. Clinical interpretation and implications of whole-genome sequencing. JAMA. 2014; 311: 1035-1045.

[2]	Pacesa M, Pelea O, Jinek M. Past, present, and future of CRISPR genome editing technologies. Cell. 2024; 187: 1076-1100.

[3]	Petri K, D'Ippolito E, Künkele A, et al. Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities. Nat Rev Clin Oncol. 2025; 22: 1-22.

[4]	Venter JC, Glass JI, Hutchison CA, Vashee S. Synthetic chromosomes, genomes, viruses, and cells. Cell. 2022; 185: 2708-2724.

[5]	Boeke JD, Church G, Hessel A, et al. The genome project-write. Science. 2016; 353: 126-127.

[6]	Liu Y, Zhou J, Liu D, et al. De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos. Nat Methods. 2025; 22: 1686-1697.

[7]	Liu Y, Zhou J, Liu Z, et al. Yeast nuclei–mediated precise delivery of synthetic megabase-scale human DNA into mammalian embryos. Nat Protoc. 2026. doi: https://doi.org/10.1038/s41596-026-01374-6. Epub ahead of print.

[8]	Delivering intact, naive, synthetic megabase-scale human DNA into mammalian embryos using SynNICE. Nat Methods. 2025; 22: 1632-1633.

[9]	Elisseeff J, Badylak SF, Boeke JD. Immune and genome engineering as the future of transplantable tissue. N Engl J Med. 2021; 385: 2451-2462.

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.