Unveiling non-small cell lung cancer-specific circulating Treg subtype: A paradigm shift in single-cell immunology and its clinical implications

References

[1] Yang Y, Chen X, Pan J, et al. Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes. Cell. 2024; 187: 4790-4811.e4722.

[2] Liu X, Wang DC, Powell CA, Wang X. Challenges of clinical translation from single-cell sequencing to measures in clinical biochemistry of haematology: definition of immune cell identities. Clin Transl Med. 2023; 13:e1401.

[3] Liu X, Xu G, Chen C, Song Y, Wang W, Wang X. Evaluation of pulmonary single-cell identity specificity in scRNA-seq analysis. Clin Transl Med. 2022; 12:e1132.

[4] Liu X, Liu Y, Duan W, et al. Single-cell identifies and validates human circulating Treg subtype/state Treg(fci) in non-small cell lung cancer. Signal Transduct Target Ther. 2026; 11: 211.

[5] Jin S, Lee K, Bang YJ, et al. Mapping the immune cell landscape of severe atopic dermatitis by single-cell RNA-seq. Allergy. 2024; 79: 1584-1597.

[6] Reyes M, Filbin MR, Bhattacharyya RP, et al. An immune-cell signature of bacterial sepsis. Nat Med. 2020; 26: 333-340.

[7] Zou C, Li P, Li B, Sparwasser T, Yuan J. Next steps in regulatory T cells: biology and clinical application. Cell. 2026; 189: 6-22.

[8] Li Y, Lu Y, Lin S, et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021; 22: 1175-1185.

[9] Liu X, Zhang W, Han Y, et al. FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity. Nat Commun. 2024; 15: 122.

[10] Mouly E, Chemin K, Nguyen HV, et al. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J Exp Med. 2010; 207: 2113-2125.

Rights & permissions

2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.