Protein stereo-folding and proteostasis: A new path for clinical and translational medicine

Yuhan Wang , Yuyang Qiu , Xiangdong Wang

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (7) : e70719

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Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (7) :e70719 DOI: 10.1002/ctm2.70719
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Protein stereo-folding and proteostasis: A new path for clinical and translational medicine
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Yuhan Wang, Yuyang Qiu, Xiangdong Wang. Protein stereo-folding and proteostasis: A new path for clinical and translational medicine. Clinical and Translational Medicine, 2026, 16 (7) : e70719 DOI:10.1002/ctm2.70719

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References

[1]

Gomes CM, Michele Vendruscolo M. Systems-level organization of extracellular proteostasis. Science. 2026; 391(6792): 1332-1338.

[2]

Hipp MS, Kasturi P, Hartl FU. The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol. 2019; 20(7): 421-435.

[3]

Sanchez-Molina P, Rosmus DD, Brownell D, et al. Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states. Nat Neurosci. Published online May 18, 2026.

[4]

Liu X, Duan W, Qiu Y, Li R, Song Y, Wang X. Significance of stereologically spatiotemporal cells in molecular medicine. Clin Transl Med. 2025; 15(9):e70470.

[5]

Wang X, Duan W, Liu X, Fan J. An important step to translate single-cell measurement into clinical practice: stereoscopic cells. Clin Transl Med. 2025; 15(4):e70304.

[6]

Liao S, Zhou X, Liu C, et al. Stereo-cell: spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays. Science. 2025; 389(6762):eadr0475.

[7]

Duan W, Wang M, Liu Y, Desoyer C, Baumgartner C, Wang X. Stereo cell: a new approach to the next generation of clinical precision medicine. Clin Transl Med. 2025; 15(12):e70537.

[8]

Baumgartner C. Stereo-cell: advancing spatial single-cell biology towards clinical translation. Clin Transl Med. 2025; 15(9):e70480.

[9]

Abramson J, Adler J, Dunger J, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024; 630(8016): 493-500.

[10]

Jia Y, Gao B, Tan J, et al. Deep contrastive learning enables genome-wide virtual screening. Science. 2026; 391(6781):eads9530.

[11]

Ferrari ÁJR, Dixit SM, Thibeault J, et al. Large-scale discovery, analysis and design of protein energy landscapes. Nature. Published online May 13, 2026.

[12]

Peng X, Guo R, Guo F, et al. Unified modeling of 3D molecular generation via atomic interactions with PocketXMol. Cell. 2026; 189(7): 1904-1922.e28.

[13]

Thornburg ZR, Maytin A, Kwon J, et al. Bringing the genetically minimal cell to life on a computer in 4D. Cell. 2026; 189(9): 2582-2597.e27.

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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