Improving detection of colorectal cancer: A Bayesian approach to serial circulating tumour DNA testing following curative-intent treatment.

Susanne K. Pedersen; Geraldine Laven-Law; Muktar Ahmed; Paul Hollington; Kathryn Cornthwaite; Benjamin L. Musher; Jean M. Winter; Erin L. Symonds; Graeme P. Young

doi:10.1002/ctm2.70697

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (5) :e70697 DOI: 10.1002/ctm2.70697

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Improving detection of colorectal cancer: A Bayesian approach to serial circulating tumour DNA testing following curative-intent treatment.

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Susanne K. Pedersen, Geraldine Laven-Law, Muktar Ahmed, Paul Hollington, Kathryn Cornthwaite, Benjamin L. Musher, Jean M. Winter, Erin L. Symonds, Graeme P. Young. Improving detection of colorectal cancer: A Bayesian approach to serial circulating tumour DNA testing following curative-intent treatment.. Clinical and Translational Medicine, 2026, 16 (5) : e70697 DOI:10.1002/ctm2.70697

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References

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[1]	Balboa-Barreiro V, Pertega-Diaz S, Garcia-Rodriguez T, et al. Colorectal cancer recurrence and its impact on survival after curative surgery: An analysis based on multistate models. Dig Liver Dis. 2024; 56: 1229-1236.

[2]	Verberne CJ, Zhan Z, van den Heuvel ER, et al. Survival analysis of the CEAwatch multicentre clustered randomized trial. Br J Surg. 2017; 104: 1069-1077.

[3]	Malla M, Loree JM, Kasi PM, Parikh AR. Using circulating tumour DNA in colorectal cancer: current and evolving practices. J Clin Oncol. 2022; 40: 2846-2857.

[4]	Symonds EL, Pedersen SK, Murray D, et al. Circulating epigenetic biomarkers for detection of recurrent colorectal cancer. Cancer. 2020; 126: 1460-1469.

[5]	Pedersen SK, Musher BL, LaPointe LC, et al. Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in BCAT1 and IKZF1. Cancer 2022; 128: 1921-1928.

[6]	Berthet V. The impact of cognitive biases on professionals' decision-making: a review of four occupational areas. Front Psychol. 2021; 12:802439.

[7]	Manrai AK, Bhatia G, Strymish J, et al. Medicine's uncomfortable relationship with math: calculating positive predictive value. JAMA Intern Med. 2014; 174: 991-3.

[8]	Huang X, Li Y, Song J, Berry DA. A Bayesian simulation model for breast cancer screening, incidence, treatment, and mortality. Med Decis Making. 2018; 38: 78S-88S.

[9]	Musher BL, Melson JE, Amato G, et al. Evaluation of circulating tumour DNA for methylated BCAT1 and IKZF1 to detect recurrence of stage II/stage III colorectal cancer (CRC). Cancer Epidemiol Biomarkers Prev. 2020; 29: 2702-2709.

[10]	Xu W, He Y, Wang Y, et al. Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies. BMC Med. 2020; 18: 172.

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.