Unveiling miR-451a and miR-142-3p as prognostic markers in non-small cell lung cancer via small extracellular vesicle liquid biopsy

Miranda Burdiel , Ana Arauzo-Cabrera , Julia Jiménez , Rocío Moreno-Velasco , Carlos Rodríguez-Antolín , Olga Pernía , Eva Madrid-Cardenas , Oliver Higuera , Laura Gutiérrez-Sainz , Paloma Yubero , Julia Villamayor , Itsaso Losantos-García , Nadina Erill Sagalés , Víctor González Rumayor , Javier de Castro , Inmaculada de Ibáñez de Cáceres , Olga Vera

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (3) : e70634

PDF (719KB)
Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (3) :e70634 DOI: 10.1002/ctm2.70634
LETTER TO THE JOURNAL
Unveiling miR-451a and miR-142-3p as prognostic markers in non-small cell lung cancer via small extracellular vesicle liquid biopsy
Author information +
History +
PDF (719KB)

Cite this article

Download citation ▾
Miranda Burdiel, Ana Arauzo-Cabrera, Julia Jiménez, Rocío Moreno-Velasco, Carlos Rodríguez-Antolín, Olga Pernía, Eva Madrid-Cardenas, Oliver Higuera, Laura Gutiérrez-Sainz, Paloma Yubero, Julia Villamayor, Itsaso Losantos-García, Nadina Erill Sagalés, Víctor González Rumayor, Javier de Castro, Inmaculada de Ibáñez de Cáceres, Olga Vera. Unveiling miR-451a and miR-142-3p as prognostic markers in non-small cell lung cancer via small extracellular vesicle liquid biopsy. Clinical and Translational Medicine, 2026, 16 (3) : e70634 DOI:10.1002/ctm2.70634

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.. 2018; 68: 394-424.

[2]

Reck M, Rodríguez-Abreu D, Robinson AG, et al. Five-year outcomes with pembrolizumab versus chemotherapy for metastatic non-small-cell lung cancer with PD-L1 tumor proportion score >/= 50. J Clin Oncol. 2021; 39: 2339-2349.

[3]

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020; 367:eaau6977

[4]

Burdiel M, Jiménez J, Rodríguez-Antolín C, et al. MiR-151a: a robust endogenous control for normalizing small extracellular vesicle cargo in human cancer. Biomark. Res.. 2023; 11: 94.

[5]

Vera O, Jimenez J, Pernia O, et al. DNA methylation of miR-7 is a mechanism involved in platinum response through MAFG overexpression in cancer cells. Theranostics. 2017; 7: 4118-4134.

[6]

Bai H, Wu S. miR-451: a novel biomarker and potential therapeutic target for cancer. OncoTargets and Therapy. 2019; 12: 11069-11082.

[7]

Miyashita Y, Ishikawa K, Fukushima Y, Kouwaki T, Nakamura K, Oshiumi H. Immune-regulatory microRNA expression levels within circulating extracellular vesicles correspond with the appearance of local symptoms after seasonal flu vaccination. PLoS One. 2019; 14:e0219510.

[8]

Khani AT, Sharifzad F, Mardpour S, Hassan ZM, Ebrahimi M. Tumor extracellular vesicles loaded with exogenous Let-7i and miR-142 can modulate both immune response and tumor microenvironment to initiate a powerful anti-tumor response. Cancer Lett.. 2021; 501: 200-209.

[9]

Dickman CT, Lawson J, Jabalee J, et al. Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes. Oncotarget. 2017; 8: 15252-15266.

[10]

Wang L, Liu H, Wu Q, et al. miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39. Cancer Gene Ther. 2024; 31: 1060-1069.

RIGHTS & PERMISSIONS

2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

PDF (719KB)

1

Accesses

0

Citation

Detail

Sections
Recommended

/