Alterations of the immune microenvironment with age predicts patient prognosis of gastrointestinal tract tumours

Fangzhen Li; Jingjing Chen; Junjie Wang; Qiuhong Zhu; Cuiying Chu; Zhiwen Zhang; Yuting Deng; Liang Zhang; Xu Lu; Wei Wang; Huipeng Wang; Dongxue Li; Aili Zhang; Hai-bo Wu; Wenchao Zhou

doi:10.1002/ctm2.70592

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (1) :e70592 DOI: 10.1002/ctm2.70592

LETTER TO THE JOURNAL

Alterations of the immune microenvironment with age predicts patient prognosis of gastrointestinal tract tumours

Fangzhen Li ¹^,²
, Jingjing Chen ¹^,²
, Junjie Wang ¹^,²
, Qiuhong Zhu ¹^,²
, Cuiying Chu ¹^,²
, Zhiwen Zhang ¹^,²
, Yuting Deng ¹^,²
, Liang Zhang ¹^,²
, Xu Lu ³
, Wei Wang ¹^,²
, Huipeng Wang ⁴
, Dongxue Li ³
, Aili Zhang ⁵^,⁶
, Hai-bo Wu ¹^,²
, Wenchao Zhou ¹^,²

Author information +

¹. Department of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

². Intelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

³. Department of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

⁴. Henan Key Laboratory of Genetic and Developmental Disorders, Institute of Children's Health, Henan Academy of Medical Sciences, Zhengzhou, Henan, China

⁵. Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

⁶. Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei, Anhui, China

lidongxue@ustc.edu.cn

ailizhang829@163.com

wuhaibo@ustc.edu.cn

WZAZ@ustc.edu.cn

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Fangzhen Li, Jingjing Chen, Junjie Wang, Qiuhong Zhu, Cuiying Chu, Zhiwen Zhang, Yuting Deng, Liang Zhang, Xu Lu, Wei Wang, Huipeng Wang, Dongxue Li, Aili Zhang, Hai-bo Wu, Wenchao Zhou. Alterations of the immune microenvironment with age predicts patient prognosis of gastrointestinal tract tumours. Clinical and Translational Medicine, 2026, 16(1): e70592 DOI:10.1002/ctm2.70592

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.