DNA methylation variability in pediatric aplastic anaemia contributes to T-cell differentiation

Junchen Lai; Fangli Chen; Yan Miao; Manpin Zhang; Hua Zhu; Huanhuan Liang; Liting Yang; Yingwen Zhang; Dabin Tang; Chengjuan Luo; Changying Luo; Yanxin Li; Xiaodong Wang; Yu Liu; Jing Chen; Xia Qin; Xinan Wang

doi:10.1002/ctm2.70588

Clinical and Translational Medicine ›› 2026, Vol. 16 ›› Issue (1) :e70588 DOI: 10.1002/ctm2.70588

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DNA methylation variability in pediatric aplastic anaemia contributes to T-cell differentiation

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¹. Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

². Department of Hematology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

³. Laboratory Department II, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁴. Cell Therapy Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁵. Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children's Medical Center, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁶. Hainan Branch of Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Hainan, China

⁷. Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

qinxia@scmc.com.cn

wangxinan@scmc.com.cn

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Junchen Lai, Fangli Chen, Yan Miao, Manpin Zhang, Hua Zhu, Huanhuan Liang, Liting Yang, Yingwen Zhang, Dabin Tang, Chengjuan Luo, Changying Luo, Yanxin Li, Xiaodong Wang, Yu Liu, Jing Chen, Xia Qin, Xinan Wang. DNA methylation variability in pediatric aplastic anaemia contributes to T-cell differentiation. Clinical and Translational Medicine, 2026, 16(1): e70588 DOI:10.1002/ctm2.70588

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References

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2026 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.