Remote-controlled genetics: A new frontier in precision therapy

Zhihua Lin; Martin Fussenegger

doi:10.1002/ctm2.70553

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (12) :e70553 DOI: 10.1002/ctm2.70553

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Remote-controlled genetics: A new frontier in precision therapy

Zhihua Lin ¹
, Martin Fussenegger ¹^,²

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Zhihua Lin, Martin Fussenegger. Remote-controlled genetics: A new frontier in precision therapy. Clinical and Translational Medicine, 2025, 15(12): e70553 DOI:10.1002/ctm2.70553

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References

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[1]	Mansouri M, Hussherr MD, Strittmatter T, et al. Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes. Nat Comm. 2021; 12: 3388.

[2]	Zhou Y, Kong D, Wang X, et al. A small and highly sensitive red/far-red optogenetic switch for applications in mammals. Nat Biotechnol. 2022; 40: 262.

[3]	Zhao H, Xue S, Hussherr MD, Buchmann P, Teixeira AP, Fussenegger M. Tuning of cellular insulin release by music for real-time diabetes control. Lancet Diabetes Endocrinol. 2023; 11: 637.

[4]	Romero G, Park J, Koehler F, Pralle A, Anikeeva P. Modulating cell signalling in vivo with magnetic nanotransducers. Nat Rev Methods Primers. 2022; 2: 92.

[5]	Lin Z, Guha Ray P, Huang J, Buchmann P, Fussenegger M. Electromagnetic wireless remote control of mammalian transgene expression. Nat Nanotech. 2025; 20: 1071.

[6]	Huang J, Xue S, Buchmann P, Teixeira AP, Fussenegger M. An electrogenetic interface to program mammalian gene expression by direct current. Nat Metab. 2023; 5: 1395.

[7]	Krawczyk K, Xue S, Buchmann P, et al. Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice. Science. 2020; 368: 993.

[8]	Stefanov BA, Teixeira AP, Mansouri M, et al. Genetically Encoded Protein Thermometer Enables Precise Electrothermal Control of Transgene Expression. Adv Sci. 2021; 8:e2101813.

[9]	Zugasti I, Espinosa-Aroca L, Fidyt K, et al. CAR-T cell therapy for cancer: current challenges and future directions. Signal Transduct Target Ther. 2025; 10: 210.

[10]	Choi S-H, Shin J, Park C, et al. In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits. Nat Nanotech. 2024; 19: 1333.

[11]	Beyer HM, Kumar S, Nieke M, et al. Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures. Nat Comm 2024; 15:10470.

[12]	Tu J, Flynn CD, Yeom J, Wu Z, Kelley SO, Gao W. Wearable biomolecular sensing nanotechnologies in chronic disease management. Nat Nanotech. 2025; 20: 1388.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.