Soluble IL-2R: A potential therapeutic target for mitochondrial dysfunction in post-COVID fatigue syndrome

Laura P. Brown , Jai Joshi , Kate Kosmac , Douglas E. Long , Logan Scott , Salim El-Amouri , Ashley A. Montgomery-Yates , Anna G. Kalema , Jamie L. Sturgill , Hemendra Vekaria , Patrick G. Sullivan , Dylan Wilburn , Panagiotis Koutakis , Christine M. Latham , Christopher S. Fry , Philip A. Kern , Benjamin F. Miller , Esther E. Dupont-Versteegden , Ahmed Ismaeel , Kirby P. Mayer , Yuan Wen

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70507

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70507 DOI: 10.1002/ctm2.70507
LETTER TO THE JOURNAL

Soluble IL-2R: A potential therapeutic target for mitochondrial dysfunction in post-COVID fatigue syndrome

Author information +
History +
PDF

Cite this article

Download citation ▾
Laura P. Brown, Jai Joshi, Kate Kosmac, Douglas E. Long, Logan Scott, Salim El-Amouri, Ashley A. Montgomery-Yates, Anna G. Kalema, Jamie L. Sturgill, Hemendra Vekaria, Patrick G. Sullivan, Dylan Wilburn, Panagiotis Koutakis, Christine M. Latham, Christopher S. Fry, Philip A. Kern, Benjamin F. Miller, Esther E. Dupont-Versteegden, Ahmed Ismaeel, Kirby P. Mayer, Yuan Wen. Soluble IL-2R: A potential therapeutic target for mitochondrial dysfunction in post-COVID fatigue syndrome. Clinical and Translational Medicine, 2025, 15(10): e70507 DOI:10.1002/ctm2.70507

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Hejbol EK, Harbo T, Agergaard J, et al. Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: evidence of skeletal muscle histopathology. Eur J Neurol. 2022; 29: 2832-2841.

[2]

Appelman B, Charlton BT, Goulding RP, et al. Muscle abnormalities worsen after post-exertional malaise in long COVID. Nat Commun. 2024; 15: 17.

[3]

Yin K, Peluso MJ, Luo X, et al. Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2. Nat Immunol. 2024; 25: 218-225.

[4]

Aschman T, Schneider J, Greuel S, et al. Association between SARS-CoV-2 infection and immune-mediated myopathy in patients who have died. JAMA Neurol. 2021; 78: 948-960.

[5]

ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166: 111-117.

[6]

Latham CB, Balawender PJ, Thomas NT, et al. Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage. Free Radic Biol Med. 2023; 212: 7.

[7]

Sastry SK, Lakonishok M, Wu S, et al. Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J Cell Biol. 1999; 144: 1295-1309.

[8]

Wolf J, Waetzig GH, Chalaris A, et al. Different soluble forms of the interleukin-6 family signal transducer gp130 fine-tune the blockade of interleukin-6 trans-signaling. J Biol Chem. 2016; 291: 16186-16196.

[9]

Danieli MG, Piga MA, Paladini A, et al. Intravenous immunoglobulin as an important adjunct in the prevention and therapy of coronavirus 2019 disease. Scand J Immunol. 2021; 94: e13101.

[10]

Behan WM, More IA, Behan PO. Mitochondrial abnormalities in the postviral fatigue syndrome. Acta Neuropathol. 1991; 83(1): 61-65.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

9

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/