Longitudinal metabolomic profiling unveils dynamic biomarkers for predicting immune recovery in HIV-1 infection

Jiali Lv , Fengting Yu , Huiyu Wang , Yu Zhang , Yuqi Wang , Liting Yan , Qing Xiao , Qun Li , Cheng Wang , Shiying Li , Ronghua Jin , Tao Zhang , Junnan Li

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70502

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70502 DOI: 10.1002/ctm2.70502
LETTER TO THE JOURNAL

Longitudinal metabolomic profiling unveils dynamic biomarkers for predicting immune recovery in HIV-1 infection

Author information +
History +
PDF

Cite this article

Download citation ▾
Jiali Lv, Fengting Yu, Huiyu Wang, Yu Zhang, Yuqi Wang, Liting Yan, Qing Xiao, Qun Li, Cheng Wang, Shiying Li, Ronghua Jin, Tao Zhang, Junnan Li. Longitudinal metabolomic profiling unveils dynamic biomarkers for predicting immune recovery in HIV-1 infection. Clinical and Translational Medicine, 2025, 15(10): e70502 DOI:10.1002/ctm2.70502

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

The Joint United Nations Programme on HIV/AIDS. Global HIV & AIDS statistics – Fact sheet. 2023. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. doi: https://www.unaids.org/en/resources/fact-sheet

[2]

Zhang F, Dou Z, Ma Y, et al. Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study. Lancet Infect Dis. 2011; 11(7): 516-524.

[3]

Pasternak AO, Grijsen ML, Wit FW, et al. Cell-associated HIV-1 RNA predicts viral rebound and disease progression after discontinuation of temporary early ART. JCI Insight. 2020; 5(6).

[4]

Dirajlal-Fargo S, Alam K, Sattar A, et al. Comprehensive assessment of the arginine pathway and its relationship to inflammation in HIV. AIDS. 2017; 31(4): 533-537.

[5]

Kurz K, Teerlink T, Sarcletti M, Weiss G, Zangerle R, Fuchs D. Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers. Pharmacol Res. 2009; 60(6): 508-514.

[6]

Hudson CL, Zemlin AE, Ipp H. The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression. Clin Biochem. 2014; 51: 568-575.

[7]

Hattab S, Guiguet M, Carcelain G, et al. Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first-line combination antiretroviral therapy. HIV Med. 2015; 16(9): 553-562.

[8]

Tang WH, Wang Z, Cho L, Brennan DM, Hazen SL. Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk. J Am Coll Cardiol. 2009; 53(22): 2061-2067.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

11

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/