Decidualised endometrial stromal cell-derived extracellular vesicles induce bystander decidualisation and cAMP-mediated attenuation of natural killer cell cytotoxicity

Maryam Mousavi , Negar Vanaki , Kayhan Zarnani , Zahra Aghazadeh , Soheila Arefi , Jila Abedi-Asl , Fazel Shokri , Seyed-Alireza Razavi , Amir-Hassan Zarnani

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70500

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70500 DOI: 10.1002/ctm2.70500
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Decidualised endometrial stromal cell-derived extracellular vesicles induce bystander decidualisation and cAMP-mediated attenuation of natural killer cell cytotoxicity

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Maryam Mousavi, Negar Vanaki, Kayhan Zarnani, Zahra Aghazadeh, Soheila Arefi, Jila Abedi-Asl, Fazel Shokri, Seyed-Alireza Razavi, Amir-Hassan Zarnani. Decidualised endometrial stromal cell-derived extracellular vesicles induce bystander decidualisation and cAMP-mediated attenuation of natural killer cell cytotoxicity. Clinical and Translational Medicine, 2025, 15(10): e70500 DOI:10.1002/ctm2.70500

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References

[1]

Llorca T, Ruiz-Magaña MJ, Abadía AC, Ruiz-Ruiz C, Olivares EG. Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy. Trends Immunol. 2025; 46(2): 138-152.

[2]

Zhang Y, Wu D, Zhou C, et al. Engineered extracellular vesicles for tissue repair and regeneration. Burns Trauma. 2024; 12: tkae062.

[3]

Cai S, Xue B, Li S, et al. Methionine regulates maternal‒fetal immune tolerance and endometrial receptivity by enhancing embryonic IL-5 secretion. Cell Rep. 2025; 44(2): 115291.

[4]

Ma Q, Beal JR, Bhurke A, et al. Extracellular vesicles secreted by human uterine stromal cells regulate decidualization, angiogenesis, and trophoblast differentiation. Proc Natl Acad Sci U S A. 2022; 119(38): e2200252119.

[5]

Sakata M, Yamaguchi M, Imai T, et al. 8-Bromo-cAMP inhibits glucose transport activity in mouse placental cells in culture. J Endocrinol. 1996; 150(2): 319-327.

[6]

Deryabin P, Griukova A, Nikolsky N, Borodkina A. The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance. Cell Mol Life Sci. 2020; 77(7): 1357-1370.

[7]

Apostolov A, Mladenović D, Tilk K, et al. Multi-omics analysis of uterine fluid extracellular vesicles reveals a resemblance with endometrial tissue across the menstrual cycle: biological and translational insights. Human Reprod Open. 2025; 2025(2): hoaf010.

[8]

Koopman LA, Kopcow HD, Rybalov B, et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med. 2003; 198(8): 1201-1212.

[9]

Shokri M-R, Bozorgmehr M, Ghanavatinejad A, et al. Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells. Sci Rep. 2019; 9(1): 10007.

[10]

Jin X, Cui L, Zhao W, et al. Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56dimCD16− NK cells. Cell Mol Immunol. 2021; 18(6): 1596-1598.

[11]

de Pedro , López E, González-Nuño FM, et al. Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics. Stem Cell Res Therapy. 2023; 14(1): 187.

[12]

Utkarsh K, Srivastava N, Papayannakos C, Nayyar A, Khan A, Haque S. Breaking the silence: the role of extracellular vesicles in unraveling the diagnosis and treatment of endometriosis. Extracellular Vesicles Circ Nucleic Acids. 2023; 4(4): 599.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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