Multitemporal single-cell profiling uncovers alveolar IL1βhi neutrophils: A significant indicator of CARDS progression

Yingying Yang; Haochen Li; Peng Liu; Jinmeng Jia; Lei Wei; Xiangyu Chen; Ziqi Tan; Hantian Li; Qianlin Wang; Siyi Yuan; Liangyu Mi; Yuechuan Xue; Yi Chi; Shuaishuai Yang; Yanjie Zhao; Huaiwu He; Xuegong Zhang; Longxiang Su; Yun Long

doi:10.1002/ctm2.70479

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (10) : e70479 DOI: 10.1002/ctm2.70479

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Multitemporal single-cell profiling uncovers alveolar IL1β^hi neutrophils: A significant indicator of CARDS progression

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¹. Department of Critical Care Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

². School of Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China

³. Medical Research Center, State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

⁴. MOE Key Lab of Bioinformatics, Bioinformatics Division of BNRIST and Department of Automation, Tsinghua University, Beijing, China

⁵. 4+4 Medical Doctor Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

⁶. Department of Toxicology, School of Public Health, Qingdao University, Qingdao, Shandong, China

⁷. Department of Anesthesia, Critical Care and Pain Medicine, Center for Inflammation Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

sulongxiang@vip.163.com

ly_icu@aliyun.com

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Yingying Yang, Haochen Li, Peng Liu, Jinmeng Jia, Lei Wei, Xiangyu Chen, Ziqi Tan, Hantian Li, Qianlin Wang, Siyi Yuan, Liangyu Mi, Yuechuan Xue, Yi Chi, Shuaishuai Yang, Yanjie Zhao, Huaiwu He, Xuegong Zhang, Longxiang Su, Yun Long. Multitemporal single-cell profiling uncovers alveolar IL1β^hi neutrophils: A significant indicator of CARDS progression. Clinical and Translational Medicine, 2025, 15(10): e70479 DOI:10.1002/ctm2.70479

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References

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.