CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways

Thomas Freitag; Jana Vanessa Scheffler; Philipp Kaps; Anne Hieltscher; Björn Schneider; Daniel Dubinski; Florian Gessler; Thomas M. Freiman; Felix Wittig; Sascha Troschke-Meurer; Wendy Bergmann-Ewert; Susanne Staehlke; Lars Boeckmann; Philipp-Kjell Ficht; Christian Polley; Christian Junghanss; Burkhard Hinz; Claudia Maletzki

doi:10.1002/ctm2.70448

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (8) : e70448 DOI: 10.1002/ctm2.70448

LETTER TO THE JOURNAL

CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways

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¹. Department of Medicine, Clinic III – Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany

². Department of Neurosurgery, Rostock University Medical Center, University of Rostock, Rostock, Germany

³. Institute of Pathology, Rostock University Medical Center, University of Rostock, Rostock, Germany

⁴. Institute of Pharmacology and Toxicology, Rostock University Medical Center, University of Rostock, Rostock, Germany

⁵. Department of Pediatric Oncology and Hematology, University Medicine Greifswald, Greifswald, Germany

⁶. Core Facility for Cell Sorting & Cell Analysis, Rostock University Medical Center, University of Rostock, Rostock, Germany

⁷. Institute of Cell Biology, University Medical Center Rostock, Rostock, Germany

⁸. Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany

⁹. Department of Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Rostock, Germany

claudia.maletzki@med.uni-rostock.de

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Thomas Freitag, Jana Vanessa Scheffler, Philipp Kaps, Anne Hieltscher, Björn Schneider, Daniel Dubinski, Florian Gessler, Thomas M. Freiman, Felix Wittig, Sascha Troschke-Meurer, Wendy Bergmann-Ewert, Susanne Staehlke, Lars Boeckmann, Philipp-Kjell Ficht, Christian Polley, Christian Junghanss, Burkhard Hinz, Claudia Maletzki. CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways. Clinical and Translational Medicine, 2025, 15(8): e70448 DOI:10.1002/ctm2.70448

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References

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[8]	Simbilyabo LZ, Yang L, Wen J, Liu Z. The unfolded protein response machinery in glioblastoma genesis, chemoresistance and as a druggable target. CNS Neurosci Ther. 2024; 30: e14839.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.