Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas

Yvonne Power , Jacklyn Liu , Umar Rehman , Adelina Kjerimi , Volker Schartinger , Nicholas Counsell , Joachim Starup-Hansen , Nicola Newall , Valerie J. Lund , Ahmed Mohyeldin , Juan C. Fernandez-Miranda , Jonathan Lavezo , Zara M. Patel , Jayakar V. Nayak , Peter H. Hwang , Sebastian Brandner , Hani Marcus , Robert B. West , Matt Lechner

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (8) : e70435

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (8) : e70435 DOI: 10.1002/ctm2.70435
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Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas

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Yvonne Power, Jacklyn Liu, Umar Rehman, Adelina Kjerimi, Volker Schartinger, Nicholas Counsell, Joachim Starup-Hansen, Nicola Newall, Valerie J. Lund, Ahmed Mohyeldin, Juan C. Fernandez-Miranda, Jonathan Lavezo, Zara M. Patel, Jayakar V. Nayak, Peter H. Hwang, Sebastian Brandner, Hani Marcus, Robert B. West, Matt Lechner. Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas. Clinical and Translational Medicine, 2025, 15(8): e70435 DOI:10.1002/ctm2.70435

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Lechner M, Hu J, Brunner M, et al. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. Nat Commun. 2021; 12(1): 117.

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Botelho L, Dezonne RS, Wildemberg LE, Miranda RL, Gadelha MR, Andreiuolo F. Somatostatin receptors in pituitary somatotroph adenomas as predictors of response to somatostatin receptor ligands: a pathologist's perspective. Brain Pathol. 2025; 35(1): e13313.

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Cakir M, Dworakowska D, Grossman A. Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 2—clinical implications. J Cell Mol Med. 2010; 14(11): 2585-2591.

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Cakir M, Dworakowska D, Grossman A. Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1—molecular pathways. J Cell Mol Med. 2010; 14(11): 2570-2584.

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Fuchs TL, Sioson L, Sheen A, Clarkson A, Gill AJ. Immunohistochemical expression of somatostatin receptors SSTR2A and SSTR5 in 299 pituitary adenomas. Pathology. 2018; 50(4): 472-474.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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