Novel cancer-associated secretory cells and IL-1β+ macrophages as key players in early lung adenocarcinoma progression in female never-smokers

Junsu Choe , Jinyeong Lim , Noeul Kang , Eun Seop Seo , Mina Hwang , Kyung Yeon Han , Se-Hoon Lee , Myung-Ju Ahn , Yoon-La Choi , Hong Kwan Kim , Woong-Yang Park , Sang-Won Um

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (8) : e70433

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (8) : e70433 DOI: 10.1002/ctm2.70433
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Novel cancer-associated secretory cells and IL-1β+ macrophages as key players in early lung adenocarcinoma progression in female never-smokers

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Junsu Choe, Jinyeong Lim, Noeul Kang, Eun Seop Seo, Mina Hwang, Kyung Yeon Han, Se-Hoon Lee, Myung-Ju Ahn, Yoon-La Choi, Hong Kwan Kim, Woong-Yang Park, Sang-Won Um. Novel cancer-associated secretory cells and IL-1β+ macrophages as key players in early lung adenocarcinoma progression in female never-smokers. Clinical and Translational Medicine, 2025, 15(8): e70433 DOI:10.1002/ctm2.70433

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References

[1]

Travis WD, Brambilla E, Nicholson AG, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 2015; 10(9): 1243-1260.

[2]

Kim N, Kim HK, Lee K, et al. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun. 2020; 11(1): 2285.

[3]

Zhang P, He B, Cai Q, et al. Decreased IL-6 and NK cells in early-stage lung adenocarcinoma presenting as ground-glass opacity. Front Oncol. 2021; 11: 705888.

[4]

Li R, Ong SL, Tran LM, et al. Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer. Sci Rep. 2020; 10(1): 377.

[5]

Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet. 2017; 390(10105): 1833-1842.

[6]

Caronni N, La Terza F, Vittoria FM, et al. IL-1β(+) macrophages fuel pathogenic inflammation in pancreatic cancer. Nature. 2023; 623(7986): 415-422.

[7]

Xu L, Lu C, Huang Y, et al. SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker. BMB Rep. 2018; 51(12): 648-653.

[8]

Zhang X, Han X, Zuo P, Zhang X, Xu H. CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration. J Int Med Res. 2020; 48(9): 300060520959478.

[9]

Kim EY, Cha YJ, Jeong S, Chang YS. Overexpression of CEACAM6 activates Src-FAK signaling and inhibits anoikis, through homophilic interactions in lung adenocarcinomas. Transl Oncol. 2022; 20: 101402.

[10]

ClinicalTrials.gov. Study of BAY1834942 in Patients with Solid Tumors. Clinical Trial Registration NCT03596372. 2022. Accessed December 29, 2024. https://clinicaltrials.gov/study/NCT03596372

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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