Unlocking the therapeutic potential of ATR inhibitors: Advances, challenges, and opportunities in cancer therapy

Tejaswini P Reddy , Timothy A. Yap

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (7) : e70397

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (7) : e70397 DOI: 10.1002/ctm2.70397
INVITED LETTER

Unlocking the therapeutic potential of ATR inhibitors: Advances, challenges, and opportunities in cancer therapy

Author information +
History +
PDF

Cite this article

Download citation ▾
Tejaswini P Reddy, Timothy A. Yap. Unlocking the therapeutic potential of ATR inhibitors: Advances, challenges, and opportunities in cancer therapy. Clinical and Translational Medicine, 2025, 15(7): e70397 DOI:10.1002/ctm2.70397

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol. 2008; 9(8): 616-627.

[2]

Ngoi NYL, Pilié PG, McGrail DJ, Zimmermann M, Schlacher K, Yap TA. Targeting ATR in patients with cancer. Nat Rev Clin Oncol. 2024; 21(4): 278-293.

[3]

Pilié PG, Tang C, Mills GB, Yap TA. State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol. 2019; 16(2): 81-104.

[4]

Mateo J, Lord CJ, Serra V, et al. A decade of clinical development of PARP inhibitors in perspective. Ann Oncol. 2019; 30(9): 1437-1447.

[5]

Rafiei S, Fitzpatrick K, Liu D, et al. ATM loss confers greater sensitivity to ATR inhibition than PARP inhibition in prostate cancer. Cancer Res. 2020; 80(11): 2094-2100.

[6]

Kidiyoor GR, Li Q, Bastianello G, et al. ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nat Commun. 2020; 11(1): 4828.

[7]

Yap TA, Tan DSP, Terbuch A, et al. First-in-human trial of the oral ataxia telangiectasia and RAD3-Related (ATR) inhibitor BAY 1895344 in patients with advanced solid tumors. Cancer Discov. 2021; 11(1): 80-91.

[8]

Levy M, Ferraro GB, Planoutene M, et al. ATR inhibitor camonsertib (RP-3500) suppresses early-stage erythroblasts by mediating ferroptosis. Eur J Cancer. 2022: 174.

[9]

Yap TA, Fontana E, Lee EK, et al. Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nat Med. 2023; 29(6): 1400-1411.

[10]

Coombs CC, Zehir A, Devlin SM, et al. Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes. Cell Stem Cell. 2017; 21(3): 374-382. e374.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

8

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/