EchoBack-CAR T cells: Tuning immunity with sound

Longwei Liu; Yingxiao Wang

doi:10.1002/ctm2.70391

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (7) : e70391 DOI: 10.1002/ctm2.70391

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EchoBack-CAR T cells: Tuning immunity with sound

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car-t / immunotherapy / solid tumour / ultrasound

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Longwei Liu, Yingxiao Wang. EchoBack-CAR T cells: Tuning immunity with sound. Clinical and Translational Medicine, 2025, 15(7): e70391 DOI:10.1002/ctm2.70391

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References

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[1]	Liu L, Qu Y, Cheng L, et al. Engineering chimeric antigen receptor T cells for solid tumour therapy. Clin Transl Med. 2022; 12(12): e1141.

[2]	Liu L, Yoon CW, Yuan Z, et al. Cellular and molecular imaging of CAR-T cell-based immunotherapy. Adv Drug Delivery Rev. 2023; 203: 115135.

[3]	Liu L, He P, Wang Y, et al. Engineering sonogenetic EchoBack-CAR T cells. Cell. 2025; 188(10): 2621-2636.e2620.

[4]	Wu Y, Liu Y, Huang Z, et al. Control of the activity of CAR-T cells within tumours via focused ultrasound. Nat Biomed Eng. 2021; 5(11): 1336-1347.

[5]	Liu L, Limsakul P, Meng X, et al. Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries. Nat Comm. 2021; 12(1): 5031.

[6]	Wu Y, Huang Z, Liu Y, et al. Ultrasound control of genomic regulatory toolboxes for cancer immunotherapy. Nat Comm. 2024; 15(1): 10444.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.