Integrating spatial transcriptomics and single-cell RNA-seq dissects immune microenvironment in fatty liver regeneration

Chenhao Xu , Renyi Su , Yisu Song , Wenzhi Shu , Mengfan Yang , Zhe Yang , Xiao Xu , Xuyong Wei

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (6) : e70365

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (6) : e70365 DOI: 10.1002/ctm2.70365
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Integrating spatial transcriptomics and single-cell RNA-seq dissects immune microenvironment in fatty liver regeneration

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Chenhao Xu, Renyi Su, Yisu Song, Wenzhi Shu, Mengfan Yang, Zhe Yang, Xiao Xu, Xuyong Wei. Integrating spatial transcriptomics and single-cell RNA-seq dissects immune microenvironment in fatty liver regeneration. Clinical and Translational Medicine, 2025, 15(6): e70365 DOI:10.1002/ctm2.70365

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References

[1]

He J, Xiao C, Li C, Yang F, Du C. Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression. Liver Res. 2023; 7(2): 145-155.

[2]

Gao H, Jiang Y, Zeng G, et al. Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease. eGastroenterology. 2024; 2(4): e100104.

[3]

Chembazhi UV, Bangru S, Hernaez M, Kalsotra A. Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver. Genome Res. 2021; 31(4): 576-591.

[4]

Kuppe C, Ramirez Flores RO, Li Z, et al. Spatial multi-omic map of human myocardial infarction. Nature. 2022; 608(7924): 766-777.

[5]

Chen T, Oh S, Gregory S, Shen X, Diehl AM. Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration. JCI Insight. 2020; 5(22): e141024.

[6]

Halpern KB, Shenhav R, Matcovitch-Natan O, et al. Single-cell spatial reconstruction reveals global division of labour in the mammalian liver. Nature. 2017; 542(7641): 352-356.

[7]

Hildebrandt F, Andersson A, Saarenpaa S, et al. Spatial transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver. Nat Commun. 2021; 12(1): 7046.

[8]

Wei Y, Wang YG, Jia Y, et al. Liver homeostasis is maintained by midlobular zone 2 hepatocytes. Science. 2021; 371(6532): eabb1625.

[9]

Valizadeh A, Majidinia M, Samadi-Kafil H, Yousefi M, Yousefi B. The roles of signaling pathways in liver repair and regeneration. J Cell Physiol. 2019; 234(9): 14966-14974.

[10]

Zhao L, Jin Y, Donahue K, et al. Tissue repair in the mouse liver following acute carbon tetrachloride depends on injury-induced Wnt/beta-catenin signaling. Hepatology. 2019; 69(6): 2623-2635.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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