Targeting biomolecular condensates to inhibit breast cancer

Xiaoxue Zhou , Linghui Zeng , Fangfang Zhou

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (4) : e70296

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (4) : e70296 DOI: 10.1002/ctm2.70296
INVITED LETTER

Targeting biomolecular condensates to inhibit breast cancer

Author information +
History +
PDF

Cite this article

Download citation ▾
Xiaoxue Zhou, Linghui Zeng, Fangfang Zhou. Targeting biomolecular condensates to inhibit breast cancer. Clinical and Translational Medicine, 2025, 15(4): e70296 DOI:10.1002/ctm2.70296

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin.2023; 73: 17-48.

[2]

Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016; 13: 674-690.

[3]

Shin Y, Brangwynne CP. Liquid phase condensation in cell physiology and disease. Science.2017; 357.

[4]

Banani SF, Lee HO, Hyman AA, Rosen MK. Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol. 2017; 18: 285-298.

[5]

Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A phase separation model for transcriptional control. Cell. 2017; 169: 13-23.

[6]

Alberti S, Hyman AA. Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat Rev Mol Cell Biol. 2021; 22: 196-213.

[7]

Klein IA, Boija A, Afeyan LK, et al. Partitioning of cancer therapeutics in nuclear condensates. Science. 2020; 368: 1386-1392.

[8]

Nozawa R-S, Yamamoto T, Takahashi M, et al. Nuclear microenvironment in cancer: control through liquid-liquid phase separation. Cancer Sci. 2020; 111: 3155-3163.

[9]

Wang B, Zhang L, Dai T, et al. Liquid-liquid phase separation in human health and diseases. Signal Transduct Target Ther. 2021; 6: 290.

[10]

Xie F, Zhou X, Ran Yu, et al. Targeting FOXM1 condensates reduces breast tumour growth and metastasis. Nature. 2025; 638: 1112-1121.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

8

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/