MS-based multi-dimensional metabolomics reveals protective effect of Polygalae Radix against metabolic disturbances in Alzheimer's disease mice

Yanwen Chen; Lisha Zhao; Shuo Cai; Yuchen Zou; Weiwei Tang; Bin Li

doi:10.1002/ctm2.70292

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (4) : e70292 DOI: 10.1002/ctm2.70292

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MS-based multi-dimensional metabolomics reveals protective effect of Polygalae Radix against metabolic disturbances in Alzheimer's disease mice

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Yanwen Chen, Lisha Zhao, Shuo Cai, Yuchen Zou, Weiwei Tang, Bin Li. MS-based multi-dimensional metabolomics reveals protective effect of Polygalae Radix against metabolic disturbances in Alzheimer's disease mice. Clinical and Translational Medicine, 2025, 15(4): e70292 DOI:10.1002/ctm2.70292

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References

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[1]	Tournissac M, Leclerc M, Valentin-Escalera J, et al. Metabolic determinants of Alzheimer's disease: a focus on thermoregulation. Ageing Res Rev. 2021; 72.

[2]	Munoz-Moreno E, Simoes RV, Tudela R, et al. Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Sci Rep. 2022; 12: 16958.

[3]	Graham SF, Holscher C, McClean P, et al. 1H NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma. Metabolomics. 2013; 9: 974-983.

[4]	Zeng W, Wu AG, Zhou XG, et al. Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota. Pharmacol Res. 2021; 170: 105697.

[5]	Zhao X, Cui Y, Wu P, et al. Polygalae Radix: a review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics. Fitoterapia. 2020; 147: 104759.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.