Severe SARS-CoV-2 infection in diabetes was rescued in mice supplemented with metformin and/or αKG, and patients taking metformin, via HIF1α-IFN axis

Garima Joshi; Garima Verma; Simrandeep Kaur; Ellango Ramasamy; Navya Chauhan; Savita Singh; Pradipta Jana; Zaigham Abbas Rizvi; Pallavi Kshetrapal; Shinjini Bhatnagar; Anil Kumar Pandey; Amit Awasthi; Bhabatosh Das; Prasenjit Guchhait

doi:10.1002/ctm2.70275

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (4) : e70275 DOI: 10.1002/ctm2.70275

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Severe SARS-CoV-2 infection in diabetes was rescued in mice supplemented with metformin and/or αKG, and patients taking metformin, via HIF1α-IFN axis

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Garima Joshi, Garima Verma, Simrandeep Kaur, Ellango Ramasamy, Navya Chauhan, Savita Singh, Pradipta Jana, Zaigham Abbas Rizvi, Pallavi Kshetrapal, Shinjini Bhatnagar, Anil Kumar Pandey, Amit Awasthi, Bhabatosh Das, Prasenjit Guchhait. Severe SARS-CoV-2 infection in diabetes was rescued in mice supplemented with metformin and/or αKG, and patients taking metformin, via HIF1α-IFN axis. Clinical and Translational Medicine, 2025, 15(4): e70275 DOI:10.1002/ctm2.70275

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.