Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression
Feng Zhao , Rui An , Yilei Ma , Shaobo Yu , Yuzhen Gao , Yanzhong Wang , Haitao Yu , Xinyou Xie , Jun Zhang
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70273
Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression
•Intratumoral Fusobacterium nucleatum exhibits significant spatial heterogeneity within breast cancer tissues. | |
•F. nucleatum colonization alters the expression of key proteins involved in tumour progression and migration. | |
•The MAPK signalling pathway is a critical mediator of F. nucleatum-induced breast cancer cell proliferation and migration. | |
•VEGFD and PAK1 are potential therapeutic targets to mitigate F. nucleatum-induced tumour progression. |
breast cancer / Fusobacterium nucleatum / intratumoral microbiota / spatial multi-omics / tumour microenvironment
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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