PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma

Zeyu Wang; Hao Wu; Zhaoxing Li; Zhukai Chen; Anqi Feng; Yuan Chu; Kang Fang; Zehua Zhang; Ziying Zhao; Zhuyun Leng; Shihan Zhang; Xiaoyuan Wang; Lingnan He; Tao Chen; Meidong Xu

doi:10.1002/ctm2.70272

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70272 DOI: 10.1002/ctm2.70272

RESEARCH ARTICLE

PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma

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Abstract

	•The role of citrullinization in cisplatin resistance of OSCC.
	•PADI4 citrullinate of PRMT2 and stabilize PRMT2.
	•PADI4 citrullinate of PRMT2 promoting the transcription of IDs family (ID1, ID2 and ID3) via histone arginine methylation.
	•PADI4 citrullinated PRMT2 affected the combination of PRMT2 and USP7.
	•PADI4 citrullinate of PRMT2 at R312 site.
	•PADI4 inhibitor GSK484 can affect the stemness of OSCC and cisplatin resistance.

Keywords

cisplatin / citrullination / OSCC / PADI4 / PRMT2

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Zeyu Wang,Hao Wu,Zhaoxing Li,Zhukai Chen,Anqi Feng,Yuan Chu,Kang Fang,Zehua Zhang,Ziying Zhao,Zhuyun Leng,Shihan Zhang,Xiaoyuan Wang,Lingnan He,Tao Chen,Meidong Xu. PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma. Clinical and Translational Medicine, 2025, 15(3): e70272 DOI:10.1002/ctm2.70272

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.