PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma

Abstract

	•The role of citrullinization in cisplatin resistance of OSCC.
	•PADI4 citrullinate of PRMT2 and stabilize PRMT2.
	•PADI4 citrullinate of PRMT2 promoting the transcription of IDs family (ID1, ID2 and ID3) via histone arginine methylation.
	•PADI4 citrullinated PRMT2 affected the combination of PRMT2 and USP7.
	•PADI4 citrullinate of PRMT2 at R312 site.
	•PADI4 inhibitor GSK484 can affect the stemness of OSCC and cisplatin resistance.

Keywords

cisplatin / citrullination / OSCC / PADI4 / PRMT2

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RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.