Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV
Ke Xu , Xinyu Zhang , Kesava Asam , Bryan C. Quach , Grier P. Page , Deborah Konkle-Parker , Claudia Martinez , Cecile D. Lahiri , Elizabeth F. Topper , Mardge H. Cohen , Seble G. Kassaye , Jack DeHovitz , Mark H. Kuniholm , Nancie M. Archin , Amir Valizadeh , Phyllis C. Tien , Vincent C. Marconi , Dana B. Hancock , Eric O. Johnson , Bradley E. Aouizerat
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70267
Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV
•Study involved 427 women with HIV. | |
•Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV-1 reservoir. | |
•Highlighted genes are involved in viral replication, immune defence, and host genome integration. | |
•Findings suggest potential molecular targets for eradication strategies. |
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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