Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV

Abstract

	•Study involved 427 women with HIV.
	•Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV-1 reservoir.
	•Highlighted genes are involved in viral replication, immune defence, and host genome integration.
	•Findings suggest potential molecular targets for eradication strategies.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.