Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV

Ke Xu; Xinyu Zhang; Kesava Asam; Bryan C. Quach; Grier P. Page; Deborah Konkle-Parker; Claudia Martinez; Cecile D. Lahiri; Elizabeth F. Topper; Mardge H. Cohen; Seble G. Kassaye; Jack DeHovitz; Mark H. Kuniholm; Nancie M. Archin; Amir Valizadeh; Phyllis C. Tien; Vincent C. Marconi; Dana B. Hancock; Eric O. Johnson; Bradley E. Aouizerat

doi:10.1002/ctm2.70267

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70267 DOI: 10.1002/ctm2.70267

RESEARCH ARTICLE

Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV

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¹. Department of Psychiatry, School of Medicine, Yale University, New Haven, Connecticut, USA

². VA Connecticut Healthcare System,West Haven, Connecticut, USA

³. Department of Oral and Maxillofacial Surgery, New York University, New York, New York, USA

⁴. Translational Research Center, New York University, New York, New York, USA

⁵. GenOmics and Translational Research Center, RTI International, Research Triangle Park, North Carolina, USA

⁶. Fellow Program, RTI International, Research Triangle Park, North Carolina, USA

⁷. Schools of Nursing, Medicine, and Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA

⁸. Miller School of Medicine, Division of Cardiovascular Medicine, University of Miami, Miami, Florida, USA

⁹. Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA

¹⁰. Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

¹¹. Department of Medicine, Stroger Hospital, Cook County Health System, Chicago, Illinois, USA

¹². Department of Medicine, Division of Infectious Diseases, Georgetown University,Washington, District of Columbia, USA

¹³. Department of Medicine, Division of Infectious Diseases, Downstate Health Sciences University, Brooklyn, New York, USA

¹⁴. Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, USA

¹⁵. UNC HIV Cure Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA

¹⁶. Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA

¹⁷. Department of Medicine, University of California at San Francisco, San Francisco, California, USA

¹⁸. Hubert Department of Global Health, Rollins School of Public Health, Atlanta, Georgia, USA

¹⁹. Atlanta VA Medical Center, Decatur, Georgia, USA

ke.xu@yale.edu

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Abstract

	•Study involved 427 women with HIV.
	•Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV-1 reservoir.
	•Highlighted genes are involved in viral replication, immune defence, and host genome integration.
	•Findings suggest potential molecular targets for eradication strategies.

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Ke Xu, Xinyu Zhang, Kesava Asam, Bryan C. Quach, Grier P. Page, Deborah Konkle-Parker, Claudia Martinez, Cecile D. Lahiri, Elizabeth F. Topper, Mardge H. Cohen, Seble G. Kassaye, Jack DeHovitz, Mark H. Kuniholm, Nancie M. Archin, Amir Valizadeh, Phyllis C. Tien, Vincent C. Marconi, Dana B. Hancock, Eric O. Johnson, Bradley E. Aouizerat. Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV. Clinical and Translational Medicine, 2025, 15(3): e70267 DOI:10.1002/ctm2.70267

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.