Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”
Bao Sun , Jin-Gang Yang , Zhe Wang , Zheng Wang , Wei Feng , Xing Li , Sheng-Nan Liu , Jiang Li , Ya-Qin Zhu , Ping Zhang , Wei Wang
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70266
Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”
•METTL14 controls osteoclast-mediated bone resorption by means of the methylation (4249 A) of the NFATc1 gene during osteoclast differentiation. | |
•Exon junction complexes (EJCs) protect the remaining methylation sites of the NFATc1 gene (located in the inner exon fragment of 50–200 nt) from hypermethylation and degradation. | |
•The “shield effect” disappears when the exon fragment is extended to 300 nt. Downstream, YTHDF2 induced the degradation of hypermethylation NFATc1 transcripts without site restriction. |
exon junction complexes / m6A distribution characteristics / osteoclast / osteoporosis / shield effect
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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