Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation

Zixian Wei; Liqing Bao; Bowen Li; Jinhua Yang; Jijiao Wang; Fangqi Xu; Hubin Wenren; Kunyu Zhang; Shang Shi; Liying Yan; Xin Tao; Tianqi Zhang; Zhiyue Wang; Yang Liu

doi:10.1002/ctm2.70262

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70262 DOI: 10.1002/ctm2.70262

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Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation

Zixian Wei ¹^,²
, Liqing Bao ¹^,³
, Bowen Li ¹^,³
, Jinhua Yang ¹^,³
, Jijiao Wang ¹^,³
, Fangqi Xu ¹^,³
, Hubin Wenren ¹^,³
, Kunyu Zhang ¹^,³
, Shang Shi ⁴
, Liying Yan ¹^,³
, Xin Tao ¹^,³
, Tianqi Zhang ¹^,³
, Zhiyue Wang ¹^,³^,^†
, Yang Liu ¹^,³^,^†

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Zixian Wei,Liqing Bao,Bowen Li,Jinhua Yang,Jijiao Wang,Fangqi Xu,Hubin Wenren,Kunyu Zhang,Shang Shi,Liying Yan,Xin Tao,Tianqi Zhang,Zhiyue Wang,Yang Liu. Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation. Clinical and Translational Medicine, 2025, 15(3): e70262 DOI:10.1002/ctm2.70262

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.