Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation

Zixian Wei; Liqing Bao; Bowen Li; Jinhua Yang; Jijiao Wang; Fangqi Xu; Hubin Wenren; Kunyu Zhang; Shang Shi; Liying Yan; Xin Tao; Tianqi Zhang; Zhiyue Wang; Yang Liu

doi:10.1002/ctm2.70262

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70262 DOI: 10.1002/ctm2.70262

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Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation

Zixian Wei ¹^,²
, Liqing Bao ¹^,³
, Bowen Li ¹^,³
, Jinhua Yang ¹^,³
, Jijiao Wang ¹^,³
, Fangqi Xu ¹^,³
, Hubin Wenren ¹^,³
, Kunyu Zhang ¹^,³
, Shang Shi ⁴
, Liying Yan ¹^,³
, Xin Tao ¹^,³
, Tianqi Zhang ¹^,³
, Zhiyue Wang ¹^,³^,^†
, Yang Liu ¹^,³^,^†

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Zixian Wei, Liqing Bao, Bowen Li, Jinhua Yang, Jijiao Wang, Fangqi Xu, Hubin Wenren, Kunyu Zhang, Shang Shi, Liying Yan, Xin Tao, Tianqi Zhang, Zhiyue Wang, Yang Liu. Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation. Clinical and Translational Medicine, 2025, 15(3): e70262 DOI:10.1002/ctm2.70262

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References

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.