LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis

Yujie Zhou; Zhen Zhao; Cheng Jiang; Chuansheng Nie; Dongdong Xiao; Zhipeng Wu; Hao Yu; Jianglin Zheng; Xuan Wang; Xiaobing Jiang

doi:10.1002/ctm2.70257

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70257 DOI: 10.1002/ctm2.70257

RESEARCH ARTICLE

LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis

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Abstract

	•LINC01088 is transcriptionally upregulated by SP1.
	•LINC01088 acts as a scaffold platform to bind USP7 and HLTF.
	•USP7, as a deubiquitinating enzyme of HLTF, participates in inhibiting the ubiquitin-proteasome degradation of HLTF.
	•HLTF transcriptionally upregates the expression of downstream SLC7A11, and ferroptosis of GBM cells was inhibited.

Keywords

cystine transporter / ferroptosis / glioblastoma / LncRNA / transcription factor

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Yujie Zhou, Zhen Zhao, Cheng Jiang, Chuansheng Nie, Dongdong Xiao, Zhipeng Wu, Hao Yu, Jianglin Zheng, Xuan Wang, Xiaobing Jiang. LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis. Clinical and Translational Medicine, 2025, 15(3): e70257 DOI:10.1002/ctm2.70257

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.