Long-term impact of obesity: Unraveling adipose epigenetic memory

Laura C. Hinte , Daniel Castellano-Castillo , Ferdinand von Meyenn

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70254

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70254 DOI: 10.1002/ctm2.70254
INVITED LETTER

Long-term impact of obesity: Unraveling adipose epigenetic memory

Author information +
History +
PDF

Keywords

Adipose Tissue / Cellular Memory / Epigenetics / Obesity / Weight Loss

Cite this article

Download citation ▾
Laura C. Hinte, Daniel Castellano-Castillo, Ferdinand von Meyenn. Long-term impact of obesity: Unraveling adipose epigenetic memory. Clinical and Translational Medicine, 2025, 15(3): e70254 DOI:10.1002/ctm2.70254

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Phelps NH, Singleton RK, Zhou B, et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-1050.

[2]

Grzelka K, Wilhelms H, Dodt S, et al. A synaptic amplifier of hunger for regaining body weight in the hypothalamus. Cell Metab. 2023;35(5):770-785.

[3]

Thaiss CA, Itav S, Rothschild D, et al. Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature. 2016;540(7634):544-551.

[4]

Hata M, Andriessen EMMA, Hata M, et al. Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation. Science. 2023;379(6627):45-62.

[5]

Cottam MA, Caslin HL, Winn NC, Hasty AH. Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice. Nat Commun. 2022;13(1):2950.

[6]

Bondareva O, Rodríguez-Aguilera JR, Oliveira F, et al. Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity. Nat Metab. 2022;4(11):1591-1610.

[7]

Contreras RE, Schriever SC, Pfluger PT. Physiological and epigenetic features of yoyo dieting and weight control. Front Genet. 2019;10:1015.

[8]

Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature. 2008;453(7196):783-787.

[9]

Hinte LC, Castellano-Castillo D, Ghosh A, et al. Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature. 2024;636(8042):457-465.

[10]

Zhou JL, de Guglielmo G, Ho AJ, et al. Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023;26(11):1868-1879.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

160

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/