Ferroptosis of T cell in inflammation and tumour immunity

Xueli Xia; Haisheng Wu; Yuxuan Chen; Huiyong Peng; Shengjun Wang

doi:10.1002/ctm2.70253

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70253 DOI: 10.1002/ctm2.70253

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Ferroptosis of T cell in inflammation and tumour immunity

Xueli Xia ¹^,²
, Haisheng Wu ²^,³
, Yuxuan Chen ²
, Huiyong Peng ⁴^,^†
, Shengjun Wang ¹^,²^,^†

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Abstract

	•Ferroptosis-related mechanisms significantly affect the biology of CD4⁺ T-cell subsets and are further involved in inflammatory diseases.
	•Crosstalk between CD8⁺ T cells and tumour cells induces ferroptosis in the tumour microenvironment.
	•Glutathione peroxidase 4 loss promotes regulatory T-cell ferroptosis to enhance anti-tumour immunity.

Keywords

CD4 ⁺ T cell / CD8 ⁺ T cell / ferroptosis / inflammation / tumour

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Xueli Xia, Haisheng Wu, Yuxuan Chen, Huiyong Peng, Shengjun Wang. Ferroptosis of T cell in inflammation and tumour immunity. Clinical and Translational Medicine, 2025, 15(3): e70253 DOI:10.1002/ctm2.70253

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.