Ferroptosis of T cell in inflammation and tumour immunity

Abstract

	•Ferroptosis-related mechanisms significantly affect the biology of CD4+ T-cell subsets and are further involved in inflammatory diseases.
	•Crosstalk between CD8+ T cells and tumour cells induces ferroptosis in the tumour microenvironment.
	•Glutathione peroxidase 4 loss promotes regulatory T-cell ferroptosis to enhance anti-tumour immunity.

Keywords

CD4 ⁺ T cell / CD8 ⁺ T cell / ferroptosis / inflammation / tumour

References

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.