An adoptive cell therapy with TREM2-overexpressing macrophages mitigates the transition from acute kidney injury to chronic kidney disease

Yating Zhang; Yu Liu; Siweier Luo; Hanzhi Liang; Chipeng Guo; Yufei Du; Hongyu Li; Le Wang; Xiaohua Wang; Chun Tang; Yiming Zhou

doi:10.1002/ctm2.70252

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70252 DOI: 10.1002/ctm2.70252

RESEARCH ARTICLE

An adoptive cell therapy with TREM2-overexpressing macrophages mitigates the transition from acute kidney injury to chronic kidney disease

Yating Zhang ¹^,²
, Yu Liu ³
, Siweier Luo ¹^,²
, Hanzhi Liang ⁴
, Chipeng Guo ¹^,²
, Yufei Du ¹^,²
, Hongyu Li ⁴
, Le Wang ¹^,²
, Xiaohua Wang ³^,^†
, Chun Tang ³^,^†
, Yiming Zhou ¹^,²^,^†

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Abstract

	•TREM2 knockout worsens kidney injury and accelerates AKI–CKD transition.
	•TREM2 is upregulated by hypoxia via HIF1α in AKI–CKD transition.
	•An adoptive cell therapy using TREM2-overexpressing macrophages reduces kidney inflammation and fibrosis.

Keywords

AKI–CKD transition / cell therapy / kidney disease / macrophages / TREM2

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Yating Zhang,Yu Liu,Siweier Luo,Hanzhi Liang,Chipeng Guo,Yufei Du,Hongyu Li,Le Wang,Xiaohua Wang,Chun Tang,Yiming Zhou. An adoptive cell therapy with TREM2-overexpressing macrophages mitigates the transition from acute kidney injury to chronic kidney disease. Clinical and Translational Medicine, 2025, 15(3): e70252 DOI:10.1002/ctm2.70252

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.