Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction

Kaixiang Li; Runjiao Luo; Xindi Yu; Wei Dong; Guoliang Hao; Dan Hu; Ziyou Yu; Minglu Liu; Tingting Lu; Xiangying Wang; Xin Tang; Xinjun Lin; Huijing Wang; Wei Wang; Wei Fu

doi:10.1002/ctm2.70250

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70250 DOI: 10.1002/ctm2.70250

RESEARCH ARTICLE

Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction

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¹. Department of Pediatric Cardiothoracic Surgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

². Institute of Electrophysiology, Henan Academy of Innovations in Medical Science, Zhengzhou, China

³. Henan Key Laboratory of Cardiac Electrophysiology, Henan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng, China

⁴. School of Mathematical Sciences, Institute of Natural Sciences, and MOE-LSC, Shanghai Jiao Tong University, Shanghai, China

⁵. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁶. Institute of Pediatric Translational Medicine, Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁷. Basic Medical College of Bengbu Medical University, Bengbu, China

⁸. Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China

⁹. Shanghai Key Laboratory of Tissue Engineering, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

wangwei@scmc.com.cn

fuweizhulu@163.com

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Abstract

	•ModRNAs-transfected hADSCs exhibit pulsed and transient expression, enabling efficient production of functional VEGFA and bFGF proteins.
	•Intracardiac injection of these engineered hADSCs leads to the enhancement of cardiac function and the improvement of electrical conduction.
	•The hADSCs^dual mainly exerts its effect on myocardial infarction by promoting stable vascular regeneration and suppressing cell apoptosis.

Keywords

bFGF / cell therapy / human adipose-derived stem cell / modRNA / myocardial infarction / VEGF

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Kaixiang Li, Runjiao Luo, Xindi Yu, Wei Dong, Guoliang Hao, Dan Hu, Ziyou Yu, Minglu Liu, Tingting Lu, Xiangying Wang, Xin Tang, Xinjun Lin, Huijing Wang, Wei Wang, Wei Fu. Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction. Clinical and Translational Medicine, 2025, 15(3): e70250 DOI:10.1002/ctm2.70250

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.