Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1KO mice

Yichen Yang; Zhihe Xue; Jiayong Lai; Jinglan Zhang; Changmiao Pang; Jinglin Zhong; Zhanpeng Kuang; Baojuan Zou; Yaqing Liu; Liangzhong Sun

doi:10.1002/ctm2.70245

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70245 DOI: 10.1002/ctm2.70245

RESEARCH ARTICLE

Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1^KO mice

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Abstract

	•Canonical Hippo pathway activated in nphp1-deficient disease models and patients.
	•Kibra was a key upstream molecule in regulating the activation of canonical Hippo pathway in nphp1-deficient disease models and patients and closely related to renal cyst formation and fibrosis in nphp1^KO mice.

Keywords

Hippo pathway / Kibra / nephronophthisis / nphp1 / renal cyst

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Yichen Yang,Zhihe Xue,Jiayong Lai,Jinglan Zhang,Changmiao Pang,Jinglin Zhong,Zhanpeng Kuang,Baojuan Zou,Yaqing Liu,Liangzhong Sun. Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1^KO mice. Clinical and Translational Medicine, 2025, 15(3): e70245 DOI:10.1002/ctm2.70245

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.