HIF-1α-induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP-ribosylation
Yangjun Wu , Yu Zeng , Yong Wu , Xinyu Ha , Zheng Feng , Chaohua Liu , Ziqi Liu , Jiajia Wang , Xingzhu Ju , Shenglin Huang , Linhui Liang , Bin Zheng , Lulu Yang , Jun Wang , Xiaohua Wu , Shengli Li , Hao Wen
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70244
HIF-1α-induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP-ribosylation
•LINC02776 promotes OC cell proliferation by regulating DNA damage and apoptosis signaling pathways. | |
•LINC02776 binds PARP1 to promote DNA damage-triggered PARylation in OC cells. | |
•LINC02776 mediates cisplatin and olaparib resistance in OC cells by enhancing PARP1-mediated PARylation activity and regulating the PARP1-mediated HR pathway. | |
•The high expression of LINC02776 is induced by HIF-1α in platinum-resistant OC cells and tissues. |
HIF-1α / LINC02776 / ovarian cancer / PARP1 / PARPi resistance / platinum resistance
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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