Id2 exacerbates the development of rheumatoid arthritis by increasing IFN-γ production in CD4+ T cells

Haoyang Sun; Jinlin Miao; Kui Zhang; Peiyan Zhang; Haomiao Shen; Jiawei Wang; Bei Zhang; Junfeng Jia; Zhaohui Zheng; Ping Zhu

doi:10.1002/ctm2.70242

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70242 DOI: 10.1002/ctm2.70242

RESEARCH ARTICLE

Id2 exacerbates the development of rheumatoid arthritis by increasing IFN-γ production in CD4⁺ T cells

Haoyang Sun ¹^,²
, Jinlin Miao ¹^,²
, Kui Zhang ¹^,²
, Peiyan Zhang ¹^,²
, Haomiao Shen ¹^,²
, Jiawei Wang ¹^,²
, Bei Zhang ¹^,²
, Junfeng Jia ¹^,²^,^†
, Zhaohui Zheng ¹^,²^,^†
, Ping Zhu ¹^,²^,^†

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Abstract

	•Pro-inflammatory cytokines are significantly upregulated in the synovial fluid T cells in rheumatoid arthritis patients.
	•The expression of pro-inflammatory cytokine interferon-γ (IFN-γ) positively correlates with the high expression of inhibitor of differentiation 2 (Id2).
	•The inhibition or ablation of Id2 can effectively suppress IFN-γ production and the onset and progression of arthritis.

Keywords

abatacept / IFN-γ / inhibitor of differentiation 2 / rheumatoid arthritis / T cell

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Haoyang Sun, Jinlin Miao, Kui Zhang, Peiyan Zhang, Haomiao Shen, Jiawei Wang, Bei Zhang, Junfeng Jia, Zhaohui Zheng, Ping Zhu. Id2 exacerbates the development of rheumatoid arthritis by increasing IFN-γ production in CD4⁺ T cells. Clinical and Translational Medicine, 2025, 15(3): e70242 DOI:10.1002/ctm2.70242

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.