Id2 exacerbates the development of rheumatoid arthritis by increasing IFN-γ production in CD4⁺ T cells

Abstract

	•Pro-inflammatory cytokines are significantly upregulated in the synovial fluid T cells in rheumatoid arthritis patients.
	•The expression of pro-inflammatory cytokine interferon-γ (IFN-γ) positively correlates with the high expression of inhibitor of differentiation 2 (Id2).
	•The inhibition or ablation of Id2 can effectively suppress IFN-γ production and the onset and progression of arthritis.

Keywords

abatacept / IFN-γ / inhibitor of differentiation 2 / rheumatoid arthritis / T cell

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.