Deciphering the secret codes in N7-methylguanosine modification: Context-dependent function of methyltransferase-like 1 in human diseases
Huan Fang , Jing He , Dan Du , Xue Wang , Xinyu Xu , Linping Lu , Yefan Zhou , Yangyang Wen , Fucheng He , Yingxia Li , Hongtao Wen , Mingxia Zhou
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70240
Deciphering the secret codes in N7-methylguanosine modification: Context-dependent function of methyltransferase-like 1 in human diseases
•METTL1-mediated m7G modification is crucial for various biological processes, including RNA stability, maturation and translation. | |
•METTL1 has emerged as a critical epigenetic modulator in human illnesses, with its dysregulated expression correlating with multiple diseases progression and presenting opportunities for both diagnostic biomarker development and molecular-targeted therapy. | |
•Enormous knowledge gaps persist regarding context-dependent regulatory networks of METTL1 and dynamic m7G modification patterns, necessitating mechanistic interrogation to bridge basic research with clinical translation in precision medicine. |
cancer progression / METTL1 / N 7-methylguanosine (m 7G) / RNA modification / therapeutic potential
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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