Detection, molecular function and mechanisms of m5C in cancer

Linhui Zhang; Yuelong Li; Liqing Li; Fei Yao; Maoping Cai; Dingwei Ye; Yuanyuan Qu

doi:10.1002/ctm2.70239

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70239 DOI: 10.1002/ctm2.70239

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Detection, molecular function and mechanisms of m5C in cancer

Linhui Zhang ¹^,²^,³
, Yuelong Li ¹
, Liqing Li ¹^,²^,³
, Fei Yao ⁴
, Maoping Cai ¹^,²^,³^,^†
, Dingwei Ye ¹^,²^,³^,^†
, Yuanyuan Qu ¹^,²^,³^,^†

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Abstract

	•m5C modifications are dynamically regulated by writers, readers, and erasers, influencing cancer progression, metastasis, and immune evasion.
	•Distinct m5C regulatory networks exist across cancers, modulating oncogenic pathways and therapy responses.
	•m5C signatures serve as biomarkers for cancer prognosis and treatment stratification, highlighting their role in precision oncology.

Keywords

5-methylcytosine / biologic functions / cancer / detection techniques / RNA modification

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Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu. Detection, molecular function and mechanisms of m5C in cancer. Clinical and Translational Medicine, 2025, 15(3): e70239 DOI:10.1002/ctm2.70239

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.