Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice
Qianqian Dong , Ziwei Liu , Yidan Ma , Xin Chen , Xiaowei Wang , Jinye Tang , Kexin Ma , Chenxi Liang , Mengyu Wang , Xiaoqin Wu , Yang Liu , Yaru Zhou , Hongyuan Yang , Mingming Gao
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70238
Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice
•Seipin-/- mice, which lack adipose tissue, exhibit significantly impaired TRAS and delayed liver regeneration following partial hepatectomy. | |
•Transplantation of normal adipose tissue into Seipin-/- mice restores TRAS and enhances liver regeneration, highlighting the essential role of adipose tissue in these processes. | |
•Liver-specific overexpression of Seipin has no effect on TRAS and liver regeneration in Seipin-/- mice. |
adipose tissue transplantation / hepatocyte proliferation / liver regeneration / partial hepatectomy / Seipin knockout mice / transient regeneration-associated steatosis (TRAS)
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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