Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice

Qianqian Dong; Ziwei Liu; Yidan Ma; Xin Chen; Xiaowei Wang; Jinye Tang; Kexin Ma; Chenxi Liang; Mengyu Wang; Xiaoqin Wu; Yang Liu; Yaru Zhou; Hongyuan Yang; Mingming Gao

doi:10.1002/ctm2.70238

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70238 DOI: 10.1002/ctm2.70238

RESEARCH ARTICLE

Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice

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Abstract

	•Seipin^-/- mice, which lack adipose tissue, exhibit significantly impaired TRAS and delayed liver regeneration following partial hepatectomy.
	•Transplantation of normal adipose tissue into Seipin^-/- mice restores TRAS and enhances liver regeneration, highlighting the essential role of adipose tissue in these processes.
	•Liver-specific overexpression of Seipin has no effect on TRAS and liver regeneration in Seipin^-/- mice.

Keywords

adipose tissue transplantation / hepatocyte proliferation / liver regeneration / partial hepatectomy / Seipin knockout mice / transient regeneration-associated steatosis (TRAS)

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Qianqian Dong, Ziwei Liu, Yidan Ma, Xin Chen, Xiaowei Wang, Jinye Tang, Kexin Ma, Chenxi Liang, Mengyu Wang, Xiaoqin Wu, Yang Liu, Yaru Zhou, Hongyuan Yang, Mingming Gao. Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice. Clinical and Translational Medicine, 2025, 15(2): e70238 DOI:10.1002/ctm2.70238

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.