Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice

Abstract

	•Seipin-/- mice, which lack adipose tissue, exhibit significantly impaired TRAS and delayed liver regeneration following partial hepatectomy.
	•Transplantation of normal adipose tissue into Seipin-/- mice restores TRAS and enhances liver regeneration, highlighting the essential role of adipose tissue in these processes.
	•Liver-specific overexpression of Seipin has no effect on TRAS and liver regeneration in Seipin-/- mice.

Keywords

adipose tissue transplantation / hepatocyte proliferation / liver regeneration / partial hepatectomy / Seipin knockout mice / transient regeneration-associated steatosis (TRAS)

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.