Advancing standards in biomedical image analysis validation: A perspective on Metrics Reloaded

Annika Reinke , Minu D Tizabi , Lena Maier-Hein

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (9) : e70237

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (9) : e70237 DOI: 10.1002/ctm2.70237
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Advancing standards in biomedical image analysis validation: A perspective on Metrics Reloaded

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Annika Reinke, Minu D Tizabi, Lena Maier-Hein. Advancing standards in biomedical image analysis validation: A perspective on Metrics Reloaded. Clinical and Translational Medicine, 2025, 15(9): e70237 DOI:10.1002/ctm2.70237

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Castro DC, Walker I, Glocker B. Causality matters in medical imaging. Nat Commun. 2020; 11(1): 3673.

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Jogan M, Kurada S, Vasisht S, Singh V, Hashimoto DA. Quality over quantity? The role of data quality and uncertainty for AI in surgery. Global Surgical Education-J Assoc Surg Edu. 2024, 3(1): 79.

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Kilim O, Olar A, Joó T, Palicz T, Pollner P, Csabai I. Physical imaging parameter variation drives domain shift. Sci Rep. 2022, 12(1): 21302.

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Maier-Hein L, Reinke A, Godau P, et al. Metrics reloaded: recommendations for image analysis validation. Nat Method. 2024, 21(2): 195-212.

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Reinke A, Tizabi MD, Baumgartner M, et al. Understanding metric-related pitfalls in image analysis validation. Nat Method. 2024, 21(2): 182-194.

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Reinke A. Eliminating flaws in biomedical image analysis validation (Doctoral dissertation). 2023

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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