Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition

Abstract

	•Irisin mediated muscle-kidney crosstalk mitigated tubular injury and inflammation.
	•Irisin inhibited the cGAS-STING signalling activation via integrin αV/β5 in tubular epithelial cells.
	•Irisin was a predictive biomarker and a promising candidate for CI-AKI.

Keywords

cGAS-STING / contrast-induced acute kidney injury / inflammation / irisin / mPGC-1α

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.