Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition
Long Peng , Suhua Li , Qiang Huang , Yuxiang Sun , Juan Sun , Ting Luo , Yanlin Wang , Zhaoyong Hu , Weiyan Lai , Hui Peng
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70235
Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition
•Irisin mediated muscle-kidney crosstalk mitigated tubular injury and inflammation. | |
•Irisin inhibited the cGAS-STING signalling activation via integrin αV/β5 in tubular epithelial cells. | |
•Irisin was a predictive biomarker and a promising candidate for CI-AKI. |
cGAS-STING / contrast-induced acute kidney injury / inflammation / irisin / mPGC-1α
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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