Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition

Long Peng; Suhua Li; Qiang Huang; Yuxiang Sun; Juan Sun; Ting Luo; Yanlin Wang; Zhaoyong Hu; Weiyan Lai; Hui Peng

doi:10.1002/ctm2.70235

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70235 DOI: 10.1002/ctm2.70235

RESEARCH ARTICLE

Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition

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Abstract

	•Irisin mediated muscle-kidney crosstalk mitigated tubular injury and inflammation.
	•Irisin inhibited the cGAS-STING signalling activation via integrin αV/β5 in tubular epithelial cells.
	•Irisin was a predictive biomarker and a promising candidate for CI-AKI.

Keywords

cGAS-STING / contrast-induced acute kidney injury / inflammation / irisin / mPGC-1α

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Long Peng, Suhua Li, Qiang Huang, Yuxiang Sun, Juan Sun, Ting Luo, Yanlin Wang, Zhaoyong Hu, Weiyan Lai, Hui Peng. Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition. Clinical and Translational Medicine, 2025, 15(3): e70235 DOI:10.1002/ctm2.70235

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.