Nuclear factor erythroid 2-related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis

Xuyun Xia; Qin Zhang; Xia Fang; Ling Li; Gangyi Yang; Xiaohui Xu; Mengliu Yang

doi:10.1002/ctm2.70233

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70233 DOI: 10.1002/ctm2.70233

RESEARCH ARTICLE

Nuclear factor erythroid 2-related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis

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Abstract

	•MAFLD is associated with increased hepatocytes NRF2 expression.
	•NRF2 alleviates MAFLD by suppressing pyroptosis.
	•NRF2 directly inhibits GSDMD expression to regulate pyroptosis.
	•Targeting the NRF2–pyroptosis (GSDMD) axis offers a potential therapeutic strategy for MAFLD.

Keywords

glucose/lipid metabolism / GSDMD / NRF2 / pyroptosis

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Xuyun Xia, Qin Zhang, Xia Fang, Ling Li, Gangyi Yang, Xiaohui Xu, Mengliu Yang. Nuclear factor erythroid 2-related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis. Clinical and Translational Medicine, 2025, 15(3): e70233 DOI:10.1002/ctm2.70233

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.